About Mediator of RNA polymerase II transcription subunit 19
Mediator of RNA polymerase II transcription subunit 19 (MED19) is a protein
from Homo sapiens identified by UniProt accession
A0JLT2, 244 residues long.
MolForge cross-references it against 0 known binders and
80 disease associations.
Target properties
| Protein name | Mediator of RNA polymerase II transcription subunit 19 |
|---|
| UniProt accession | A0JLT2 |
|---|
| Gene | MED19 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 244 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (80)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.54
- mean corpuscular volume · score 0.15
- mean corpuscular hemoglobin concentration · score 0.14
- systolic blood pressure · score 0.13
- erythrocyte count · score 0.13
- breast adenocarcinoma · score 0.11
- reticulocyte count · score 0.10
- hepatocellular carcinoma · score 0.08
- schizophrenia · score 0.07
- neuroticism measurement · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-A0JLT2-F1 | alphafold | PREDICTED | 64.79 | — |
Amino-acid sequence (244 residues)
MENFTALFGA QADPPPPPTA LGFGPGKPPP PPPPPAGGGP GTAPPPTAAT APPGADKSGA GCGPFYLMRE LPGSTELTGS TNLITHYNLE QAYNKFCGKK VKEKLSNFLP DLPGMIDLPG SHDNSSLRSL IEKPPILSSS FNPITGTMLA GFRLHTGPLP EQCRLMHIQP PKKKNKHKHK QSRTQDPVPP ETPSDSDHKK KKKKKEEDPD RKRKKKEKKK KKNRHSPDHP GMGSSQASSS SSLR
Explore Mediator of RNA polymerase II transcription subunit 19 with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets