About Shootin-1
Shootin-1 (SHTN1) is a protein
from Homo sapiens identified by UniProt accession
A0MZ66, 631 residues long.
MolForge cross-references it against 0 known binders and
181 disease associations.
Target properties
| Protein name | Shootin-1 |
|---|
| UniProt accession | A0MZ66 |
|---|
| Gene | SHTN1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 631 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (181)
Diseases linked to this target (Open Targets).
- cleft lip · score 0.43
- Cleft palate · score 0.40
- progranulin measurement · score 0.37
- cortical surface area measurement · score 0.36
- self reported educational attainment · score 0.36
- body fat percentage · score 0.35
- body mass index · score 0.34
- neuroimaging measurement · score 0.34
- brain volume measurement · score 0.33
- lean body mass · score 0.32
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-A0MZ66-F1 | alphafold | PREDICTED | 70.76 | — |
Amino-acid sequence (631 residues)
MNSSDEEKQL QLITSLKEQA IGEYEDLRAE NQKTKEKCDK IRQERDEAVK KLEEFQKISH MVIEEVNFMQ NHLEIEKTCR ESAEALATKL NKENKTLKRI SMLYMAKLGP DVITEEINID DEDSTTDTDG AAETCVSVQC QKQIKELRDQ IVSVQEEKKI LAIELENLKS KLVEVIEEVN KVKQEKTVLN SEVLEQRKVL EKCNRVSMLA VEEYEEMQVN LELEKDLRKK AESFAQEMFI EQNKLKRQSH LLLQSSIPDQ QLLKALDENA KLTQQLEEER IQHQQKVKEL EEQLENETLH KEIHNLKQQL ELLEEDKKEL ELKYQNSEEK ARNLKHSVDE LQKRVNQSEN SVPPPPPPPP PLPPPPPNPI RSLMSMIRKR SHPSGSGAKK EKATQPETTE EVTDLKRQAV EEMMDRIKKG VHLRPVNQTA RPKTKPESSK GCESAVDELK GILGTLNKST SSRSLKSLDP ENSETELERI LRRRKVTAEA DSSSPTGILA TSESKSMPVL GSVSSVTKTA LNKKTLEAEF NSPSPPTPEP GEGPRKLEGC TSSKVTFQPP SSIGCRKKYI DGEKQAEPVV VLDPVSTHEP QTKDQVAEKD PTQHKEDEGE IQPENKEDSI ENVRETDSSN C
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