Phospholipid scramblase family member 5 (PLSCR5)

About Phospholipid scramblase family member 5

Phospholipid scramblase family member 5 (PLSCR5) is a protein from Homo sapiens identified by UniProt accession A0PG75, 271 residues long. MolForge cross-references it against 0 known binders and 10 disease associations.

Target properties

Protein name	Phospholipid scramblase family member 5
UniProt accession	A0PG75
Gene	PLSCR5
Organism	Homo sapiens
Length	271 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (10)

Diseases linked to this target (Open Targets).

brain volume measurement · score 0.40
brain measurement · score 0.28
smoking status measurement · score 0.27
antisocial behaviour measurement · score 0.27
substance abuse · score 0.27
attention deficit hyperactivity disorder · score 0.27
systemic lupus erythematosus · score 0.21
PHF-tau measurement · score 0.08
benign adult familial myoclonic epilepsy · score 0.04
deafness · score 0.04

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-A0PG75-F1	alphafold	PREDICTED	72.55	—

Amino-acid sequence (271 residues)

MASKDAQNQR RGLPGFLPGA PDPDQSLPAS SNPGNQAWQL SLPLPSSFLP TVSLPPGLEY LSQLDLIIIH QQVELLGMIL GTETSNKYEI KNSLGQRIYF AVEESICFNR TFCSTLRSCT LRITDNSGRE VITVNRPLRC NSCWCPCYLQ ELEIQAPPGT IVGYVTQKWD PFLPKFTIQN ANKEDILKIV GPCVTCGCFG DVDFEVKTIN EKLTIGKISK YWSGFVNDVF TNADNFGIHV PADLDVTVKA AMIGACFLFD FMFFEHSLAG L

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards