About Rho guanine nucleotide exchange factor 37
Rho guanine nucleotide exchange factor 37 (ARHGEF37) is a protein
from Homo sapiens identified by UniProt accession
A1IGU5, 675 residues long.
MolForge cross-references it against 0 known binders and
22 disease associations.
Target properties
| Protein name | Rho guanine nucleotide exchange factor 37 |
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| UniProt accession | A1IGU5 |
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| Gene | ARHGEF37 |
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| Organism | Homo sapiens |
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| Length | 675 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (22)
Diseases linked to this target (Open Targets).
- breast adenocarcinoma · score 0.18
- glioblastoma multiforme · score 0.11
- esophageal carcinoma · score 0.10
- metabolite measurement · score 0.10
- hepatocellular carcinoma · score 0.07
- neoplasm · score 0.04
- mean platelet volume · score 0.03
- gastric carcinoma · score 0.02
- Leishmaniasis · score 0.02
- cancer · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-A1IGU5-F1 | alphafold | PREDICTED | 83.22 | — |
Amino-acid sequence (675 residues)
MAKHGADEPS SRSGSPDREG RASEDRSLLH QRLAVRELID TEVSYLHMLQ LCASDIRSRL QQLPQGDLDV LFSNIDDIIK VNSRFLHDLQ ETASKEEEQV QLVGNIFLEF QEELEQVYKV YCASYDQALL LVDTYRKEPE LQRHIQGIVE AVVPQAGSSG LSFLLVIPLQ RITRYPLLLQ KILENTVPDA SAYPVLQRAV SALQDVNTNI NEYKMRKEVA SKYTKVEQLT LRERLARINT HTLSKKTTRL SQLLKQEAGL IPRTEDKEFD DLEERFQWVS LCVTELKNNV AAYLDNLQAF LYFRPHEYNL DIPEGPAVQY CNLARDLHLE AFLKFKQRLE GLVWQPLCSL AKALLGPQNL IKKRLDKLLD FERVEEKLLE VGSVTYQEEA ARHTYQALNS LLVAELPQFN QLVMQWLGQI MCTFVTLQRD LAKQVLQRAE GSMAQLPHHH VPEPAFRKLV EDALGRTSNQ LRSFQETFEK VQPPPTTQPL LPGSERQVQA LLSRYGPGKL YQVTSNISGT GTLDLTLPRG QIVAILQNKD TKGNSGRWLV DTGGHRGYVP AGKLQLYHVV PSAEELRRQA GLNKDPRCLT PEPSPALVPS IPTMNQVIAA YPFVARSSHE VSLQAGQPVT ILEAQDKKGN PEWSLVEVNG QRGYVPSGFL ARARSPVLWG WSLPS
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