NADH dehydrogenase [ubiquinone] 1 alpha subcomplex…

About NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 8

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 8 (NDUFAF8) is a protein from Homo sapiens identified by UniProt accession A1L188, 74 residues long. MolForge cross-references it against 0 known binders and 16 disease associations.

Target properties

Protein name	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 8
UniProt accession	A1L188
Gene	NDUFAF8
Organism	Homo sapiens
Length	74 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (16)

Diseases linked to this target (Open Targets).

mitochondrial complex 1 deficiency, nuclear type 34 · score 0.71
mitochondrial disease · score 0.48
Leigh syndrome · score 0.42
mitochondrial complex I deficiency · score 0.37
genetic disorder · score 0.16
vitamin D measurement · score 0.16
age at menarche · score 0.12
serum IgG glycosylation measurement · score 0.12
IgG fucosylation measurement · score 0.08
IgG galactosylation measurement · score 0.07

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-A1L188-F1	alphafold	PREDICTED	90.86	—

Amino-acid sequence (74 residues)

MSANGAVWGR VRSRLRAFPE RLAACGAEAA AYGRCVQAST APGGRLSKDF CAREFEALRS CFAAAAKKTL EGGC

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 8 (NDUFAF8)