About Pleckstrin homology domain-containing family G member 3
Pleckstrin homology domain-containing family G member 3 (PLEKHG3) is a protein
from Homo sapiens identified by UniProt accession
A1L390, 1219 residues long.
MolForge cross-references it against 0 known binders and
36 disease associations.
Target properties
| Protein name | Pleckstrin homology domain-containing family G member 3 |
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| UniProt accession | A1L390 |
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| Gene | PLEKHG3 |
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| Organism | Homo sapiens |
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| Length | 1219 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (36)
Diseases linked to this target (Open Targets).
- mean corpuscular volume · score 0.32
- functional brain measurement · score 0.26
- cup-to-disc ratio measurement · score 0.23
- adolescent idiopathic scoliosis · score 0.20
- high density lipoprotein cholesterol measurement · score 0.20
- triglyceride measurement · score 0.20
- optic disc size measurement · score 0.19
- genetic disorder · score 0.17
- platelet component distribution width · score 0.16
- optic disc area measurement · score 0.16
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-A1L390-F1 | alphafold | PREDICTED | 54.06 | — |
Amino-acid sequence (1219 residues)
MPVSTSLHQD GSQERPVSLT STTSSSGSSC DSRSAMEEPS SSEAPAKNGA GSLRSRHLPN SNNNSSSWLN VKGPLSPFNS RAAAGPAHHK LSYLGRVVRE IVETERMYVQ DLRSIVEDYL LKIIDTPGLL KPEQVSALFG NIENIYALNS QLLRDLDSCN SDPVAVASCF VERSQEFDIY TQYCNNYPNS VAALTECMRD KQQAKFFRDR QELLQHSLPL GSYLLKPVQR ILKYHLLLQE IAKHFDEEED GFEVVEDAID TMTCVAWYIN DMKRRHEHAV RLQEIQSLLI NWKGPDLTTY GELVLEGTFR VHRVRNERTF FLFDKTLLIT KKRGDHFVYK GNIPCSSLML IESTRDSLCF TVTHYKHSKQ QYSIQAKTVE EKRNWTHHIK RLILENHHAT IPQKAKEAIL EMDSYYPNRY RCSPERLKKA WSSQDEVSTN VRQGRRQSEP TKHLLRQLNE KARAAGMKGK GRRESESSRS SRRPSGRSPT STEKRMSFES ISSLPEVEPD PEAGSEQEVF SAVEGPSAEE TPSDTESPEV LETQLDAHQG LLGMDPPGDM VDFVAAESTE DLKALSSEEE EEMGGAAQEP ESLLPPSVLD QASVIAERFV SSFSRRSSVA QEDSKSSGFG SPRLVSRSSS VLSLEGSEKG LARHGSATDS LSCQLSPEVD ISVGVATEDS PSVNGMEPPS PGCPVEPDRS SCKKKESALS TRDRLLLDKI KSYYENAEHH DAGFSVRRRE SLSYIPKGLV RNSISRFNSL PRPDPEPVPP VGSKRQVGSR PTSWALFELP GPSQAVKGDP PPISDAEFRP SSEIVKIWEG MESSGGSPGK GPGQGQANGF DLHEPLFILE EHELGAITEE SATASPESSS PTEGRSPAHL ARELKELVKE LSSSTQGELV APLHPRIVQL SHVMDSHVSE RVKNKVYQLA RQYSLRIKSN KPVMARPPLQ WEKVAPERDG KSPTVPCLQE EAGEPLGGKG KRKPVLSLFD YEQLMAQEHS PPKPSSAGEM SPQRFFFNPS AVSQRTTSPG GRPSARSPLS PTETFSWPDV RELCSKYASR DEARRAGGGR PRGPPVNRSH SVPENMVEPP LSGRVGRCRS LSTKRGRGGG EAAQSPGPLP QSKPDGGETL YVTADLTLED NRRVIVMEKG PLPSPTAGLE ESSGQGPSSP VALLGQVQDF QQSAECQPKE EGSRDPADPS QQGRVRNLRE KFQALNSVG
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