Coiled-coil domain-containing protein 78 (CCDC78)

About Coiled-coil domain-containing protein 78

Coiled-coil domain-containing protein 78 (CCDC78) is a protein from Homo sapiens identified by UniProt accession A2IDD5, 438 residues long. MolForge cross-references it against 0 known binders and 46 disease associations.

Target properties

Protein name	Coiled-coil domain-containing protein 78
UniProt accession	A2IDD5
Gene	CCDC78
Organism	Homo sapiens
Length	438 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (46)

Diseases linked to this target (Open Targets).

congenital myopathy with internal nuclei and atypical cores · score 0.63
neurodegenerative disease · score 0.22
centronuclear myopathy · score 0.21
genetic disorder · score 0.19
BMI-adjusted waist circumference · score 0.17
body height · score 0.13
lean body mass · score 0.09
bone fracture · score 0.09
BMI-adjusted hip circumference · score 0.08
fat body mass · score 0.07

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-A2IDD5-F1	alphafold	PREDICTED	65.71	—

Amino-acid sequence (438 residues)

MEHAATTGPR PGPPSRRVEN VVLRAKDWLP GAPGGTAVWA TSLEAEVPPD LALNKEQQLQ ISKELVDIQI TTHHLHEQHE AEIFQLKSEI LRLESRVLEL ELRGDGTSQG CAVPVESDPR HPRAAAQELR HKAQVPGHSD DHRFQVQPKN TMNPENEQHR LGSGLQGEVK WALEHQEARQ QALVTRVATL GRQLQGAREE ARAAGQRLAT QAVVLCSCQG QLRQAEAENA RLQLQLKKLK DEYVLRLQHC AWQAVEHADG AGQAPATTAL RTFLEATLED IRAAHRSREQ QLARAARSYH KRLVDLSRRH EELLVAYRAP GNPQAIFDIA SLDLEPLPVP LVTDFSHRED QHGGPGALLS SPKKRPGGAS QGGTSEPQGL DAASWAQIHQ KLRDFSRSTQ SWNGSGHSCW SGPRWLKSNF LSYRSTWTST WAGTSTKS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards