About Threonine--tRNA ligase 2, cytoplasmic
Threonine--tRNA ligase 2, cytoplasmic (TARS3) is a protein
from Homo sapiens identified by UniProt accession
A2RTX5, 802 residues long.
MolForge cross-references it against 0 known binders and
10 disease associations.
Target properties
| Protein name | Threonine--tRNA ligase 2, cytoplasmic |
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| UniProt accession | A2RTX5 |
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| Gene | TARS3 |
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| Organism | Homo sapiens |
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| Length | 802 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (10)
Diseases linked to this target (Open Targets).
- diabetes mellitus, permanent neonatal 4 · score 0.03
- permanent neonatal diabetes mellitus 1 · score 0.03
- MODY · score 0.03
- Duchenne muscular dystrophy · score 0.01
- viral disease · score 0.00
- infect · score 0.00
- infection · score 0.00
- BK-virus nephropathy · score 0.00
- glioblastoma multiforme · score 0.00
- progressive supranuclear palsy · score 0.00
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-A2RTX5-F1 | alphafold | PREDICTED | 87.43 | — |
Amino-acid sequence (802 residues)
MAAEALAAEA VASRLERQEE DIRWLWSEVE RLRDEQLNAP YSCQAEGPCL TREVAQLRAE NCDLRHRLCS LRLCLAEERS RQATLESAEL EAAQEAGAQP PPSQSQDKDM KKKKMKESEA DSEVKHQPIF IKERLKLFEI LKKDHQLLLA IYGKKGDTSN IITVRVADGQ TVQGEVWKTT PYQVAAEISQ ELAESTVIAK VNGELWDLDR PLEGDSSLEL LTFDNEEAQA VYWHSSAHIL GEAMELYYGG HLCYGPPIEN GFYYDMFIED RAVSSTELSA LENICKAIIK EKQPFERLEV SKEILLEMFK YNKFKCRILN EKVNTATTTV YRCGPLIDLC KGPHVRHTGK IKTIKIFKNS STYWEGNPEM ETLQRIYGIS FPDNKMMRDW EKFQEEAKNR DHRKIGKEQE LFFFHDLSPG SCFFLPRGAF IYNTLTDFIR EEYHKRDFTE VLSPNMYNSK LWEASGHWQH YSENMFTFEI EKDTFALKPM NCPGHCLMFA HRPRSWREMP IRFADFGVLH RNELSGTLSG LTRVRRFQQD DAHIFCTVEQ IEEEIKGCLQ FLQSVYSTFG FSFQLNLSTR PENFLGEIEM WNEAEKQLQN SLMDFGEPWK MNPGDGAFYG PKIDIKIKDA IGRYHQCATI QLDFQLPIRF NLTYVSKDGD DKKRPVIIHR AILGSVERMI AILSENYGGK WPFWLSPRQV MVIPVGPTCE KYALQVSSEF FEEGFMADVD LDHSCTLNKK IRNAQLAQYN FILVVGEKEK IDNAVNVRTR DNKIHGEILV TSAIDKLKNL RKTRTLNAEE AF
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