Protein TESPA1 (TESPA1)

About Protein TESPA1

Protein TESPA1 (TESPA1) is a protein from Homo sapiens identified by UniProt accession A2RU30, 521 residues long. MolForge cross-references it against 0 known binders and 125 disease associations.

Target properties

Protein name	Protein TESPA1
UniProt accession	A2RU30
Gene	TESPA1
Organism	Homo sapiens
Length	521 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (125)

Diseases linked to this target (Open Targets).

childhood onset asthma · score 0.45
asthma · score 0.39
Eczematoid dermatitis · score 0.39
atopic asthma · score 0.31
allergic rhinitis · score 0.31
neurodegenerative disease · score 0.30
allergic asthma · score 0.18
genetic disorder · score 0.12
atopic eczema · score 0.09
acute myeloid leukemia · score 0.08

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-A2RU30-F1	alphafold	PREDICTED	53.94	—

Amino-acid sequence (521 residues)

MEASVLSPTS WEKRRAWLRQ SRNWQTQVLE EEAAAALQDV PDPEPSSLDD VFQEGNPINK IEDWLQDCGY SEEGFSEEAG QFIYNGFCSH GTSFEDDLTL GAEATLLAAN GKLFSRSFLE TARPCQLLDL GCSLASSSMT GGTNKTSSSI SEILDKVQED AEDVLFSLGF GQEDHKDTSR IPARFFTTPS QAKGIDFQLF LKSQVRRIEM EDPCLMLASR FKQVQTLAVT ADAFFCLYSY VSKTPVQKFT PSHMFWNCNH PTDVPSIRIL SREPEPQSPR DRLRKAISKM CLYTCPRDRP PPPHNTPKRN SLDQVVLEVM DKVKEEKQFL QQDSDLGQFS QEDPVPPAEG KKLPTSPYPC VFCCEEETQQ RMSTVLAPSQ TLDSNPKVPC CTHSLPIEDP QWSTDPAQIR RELCSLPATN TETHPAKDET FWKRKSRARK SLFQKNLMGR KVKSLDLSIT QQKWKQSVDR PELRRSLSQQ PQDTFDLEEV QSNSEEEQSQ SRWPSRPRHP HHHQTFAGKD S

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards