Hydroxylysine kinase (HYKK)

About Hydroxylysine kinase

Hydroxylysine kinase (HYKK) is a protein from Homo sapiens identified by UniProt accession A2RU49, 373 residues long. MolForge cross-references it against 0 known binders and 83 disease associations.

Target properties

Protein name	Hydroxylysine kinase
UniProt accession	A2RU49
Gene	HYKK
Organism	Homo sapiens
Length	373 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (83)

Diseases linked to this target (Open Targets).

cigarettes per day measurement · score 0.41
emphysema pattern measurement · score 0.41
chronic obstructive pulmonary disease · score 0.38
nicotine dependence · score 0.33
vital capacity · score 0.33
forced expiratory volume · score 0.31
tobacco smoke exposure measurement · score 0.29
parental longevity · score 0.28
serum metabolite measurement · score 0.26
lung carcinoma · score 0.26

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-A2RU49-F1	alphafold	PREDICTED	93.54	—

Amino-acid sequence (373 residues)

MSSGNYQQSE ALSKPTFSEE QASALVESVF GLKVSKVRPL PSYDDQNFHV YVSKTKDGPT EYVLKISNTK ASKNPDLIEV QNHIIMFLKA AGFPTASVCH TKGDNTASLV SVDSGSEIKS YLVRLLTYLP GRPIAELPVS PQLLYEIGKL AAKLDKTLQR FHHPKLSSLH RENFIWNLKN VPLLEKYLYA LGQNRNREIV EHVIHLFKEE VMTKLSHFRE CINHGDLNDH NILIESSKSA SGNAEYQVSG ILDFGDMSYG YYVFEVAITI MYMMIESKSP IQVGGHVLAG FESITPLTAV EKGALFLLVC SRFCQSLVMA AYSCQLYPEN KDYLMVTAKT GWKHLQQMFD MGQKAVEEIW FETAKSYESG ISM

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards