About Meiosis-specific coiled-coil domain-containing protein MEIOC
Meiosis-specific coiled-coil domain-containing protein MEIOC (MEIOC) is a protein
from Homo sapiens identified by UniProt accession
A2RUB1, 952 residues long.
MolForge cross-references it against 0 known binders and
122 disease associations.
Target properties
| Protein name | Meiosis-specific coiled-coil domain-containing protein MEIOC |
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| UniProt accession | A2RUB1 |
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| Gene | MEIOC |
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| Organism | Homo sapiens |
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| Length | 952 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (122)
Diseases linked to this target (Open Targets).
- body height · score 0.08
- azoospermia · score 0.08
- male infertility with teratozoospermia due to single gene mutation · score 0.07
- partial chromosome Y deletion · score 0.07
- primary ovarian insufficiency · score 0.06
- spinocerebellar ataxia type 32 · score 0.06
- congenital bilateral absence of vas deferens · score 0.06
- isochromosomy Yp · score 0.05
- spermatogenic failure 25 · score 0.05
- lean body mass · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-A2RUB1-F1 | alphafold | PREDICTED | 46.47 | — |
Amino-acid sequence (952 residues)
MEVRRGDTCP RPHPSGLREE GLEPKVAFPG GANRCWNLGA DAGSRLTDVF GSVMLTGSAS FYDCYTSQSE DNVDLRQTYT PFSSTEYSSS VDSSLFCAPW STYGDDIKQP SNSQISIKNR IQTERNDYGS ETDLYGLVSN ILEEQDKSQP YFAEGTCSSN LKSVWPMNTS RFADHHDLLT ETKRPIDTVI SQQAFYSDES VSAMEKQYLR NSNLTPQQKI DELHHGFTGL DLEEQWMYPS RSDHSNCHNI QTNDTAKTTF QEYPLIKNCF TPQTGLSDIM KESGVDIYHY GRDRICTKGL EAPLQQKRAE MFLSQFNRYN ENVDYCRYPE YVHPNKAKLN KCSNFSVQDS KKLANGTPET PTVEADTYTK LFQVKPANQK KMEETIPDQQ NFTFPKTTPH LTEKQFAKEA VFTADFGLTS EYGLKPHTAC PANDFANVTE KQQFAKPDPP HSEYFKSVNL LSNSATSSGG INLNRPTWMN VQTKNNTPIP YRNQGNLMKL NSHLSAASKG SNHSSDFPQL SSTNLTPNSN LFQKYCQENP SAFSSFDFSY SGAERIQSVN HIEGLTKPGE ENLFKLVTDK KIKQPNGFCD NYSAQKYGII ENVNKHNFQA KPQSGHYDPE EGPKHLDGLS QNTYQDLLES QGHSNSHRTR GGDNSRVNRT QVSCFSNNYM MGDLRHNQCF QQLGSNGFPL RSTHPFGHSV VPLLDSYDLL SYDDLSHLYP YFNMMYGDNS FSGLMPTFGF QRPIKTRSGP ASELHIRLEE CCEQWRALEK ERKKTELALA KNYPGKKVSS TNNTPVPRLT SNPSRVDRLI VDELRELARV VTLLGKMERL RSSLLHASIS TALDRHLESI HIVQSRRKDE IVNASNRQRQ GVPRCQDDRD VFALASAIKE MCVATRKTRT ALWCALQMTL PKTASTADVV KPLQDTVNCE DKVHESINSS NPMNQRGETN KH
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