About Coiled-coil domain-containing protein 66
Coiled-coil domain-containing protein 66 (CCDC66) is a protein
from Homo sapiens identified by UniProt accession
A2RUB6, 948 residues long.
MolForge cross-references it against 0 known binders and
110 disease associations.
Target properties
| Protein name | Coiled-coil domain-containing protein 66 |
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| UniProt accession | A2RUB6 |
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| Gene | CCDC66 |
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| Organism | Homo sapiens |
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| Length | 948 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (110)
Diseases linked to this target (Open Targets).
- lean body mass · score 0.50
- mean platelet volume · score 0.43
- platelet count · score 0.42
- body height · score 0.37
- lymphocyte count · score 0.37
- sex hormone-binding globulin measurement · score 0.37
- appendicular lean mass · score 0.37
- base metabolic rate measurement · score 0.29
- fat body mass · score 0.29
- whole body water mass · score 0.28
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-A2RUB6-F1 | alphafold | PREDICTED | 56.81 | — |
Amino-acid sequence (948 residues)
MNLGDGLKLE TELLDGKTKL ILSPYEHKSK ISVKMGNKAK IAKCPLRTKT GHILKSTQDT CIGSEKLLQK KPVGSETSQA KGEKNGMTFS STKDLCKQCI DKDCLHIQKE ISPATPNMQK TRNTVNTSLV GKQKPHKKHI TAENMKSSLV CLTQDQLQQI LMTVNQGNRS LSLTENGKEA KSQYSLYLNS ISNQPKDENI MGLFKKTEMV SSVPAENKSV LNEHQETSKQ CEQKIAIENE WKPADIFSTL GERECDRSSL EAKKAQWRKE LDEQVALKKK EKEVSEKWND PWKKSESDKI IWEKHQILDQ SRETVLLEHP FSAVKQELQR KWIEELNKQI EDDRQRKIEE KIIYSKGEEH DRWAMHFDSL KSYPGSQSQL FSQSTHKQPE YFCVSPDTQE LADVSSVCTP TTGSQVEPSE EEHIAKPIKD VVMANSKKTN FLRSMTALLD PAQIEERDRR RQKQLEHQKA ITAQVEEKRR KKQLEEEQRK KEEQEEELRL AQEREEMQKQ YEEDILKQKQ KEEIMTLKTN ELFQTMQRAQ ELAQRLKQEQ RIRELAQKGH DTSRLIKNLG VDTIQMEYNA SNISNSRHDS DEISGKMNTY MNSTTSKKDT GVQTDDLNIG IFTNAESHCG SLMERDITNC SSPEISAELI GQFSTKKNKQ ELTQDKGASL EKENNRCNDQ CNQFTRIEKQ TKHMKKYPKR PDWNINKPPK RYIPASEKYP KQLQKQREEK KVRRQMELLH LVEKNNPGHL SQNRGISPEI FHSSHQETES KLRWHLVKKE EEPLNIHSFS KERSPSSPVP VVKNRTQQTQ NTLHLPLKNS SYERENLISG SNQTELSSGI SESSHFIPYV RTNEIYYLDP DAPLSGPSTQ DPQYQNSQDC GQKRQLFDSD CVRDPLLNPN MVKNRDRQQA ILKGLSELRQ GLLQKQKELE SSLLPLAENQ EESFGSSF
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