About Coiled-coil domain-containing protein 144A
Coiled-coil domain-containing protein 144A (CCDC144A) is a protein
from Homo sapiens identified by UniProt accession
A2RUR9, 1427 residues long.
MolForge cross-references it against 0 known binders and
11 disease associations.
Target properties
| Protein name | Coiled-coil domain-containing protein 144A |
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| UniProt accession | A2RUR9 |
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| Gene | CCDC144A |
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| Organism | Homo sapiens |
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| Length | 1427 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (11)
Diseases linked to this target (Open Targets).
- upper respiratory tract disorder · score 0.26
- spleen volume · score 0.16
- mean corpuscular hemoglobin · score 0.03
- mean corpuscular volume · score 0.03
- C-reactive protein measurement · score 0.02
- polycystic ovary syndrome · score 0.01
- myxosarcoma · score 0.00
- triple-negative breast cancer · score 0.00
- cancer · score 0.00
- preeclampsia · score 0.00
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-A2RUR9-F1 | alphafold | PREDICTED | 60.96 | — |
Amino-acid sequence (1427 residues)
MASWGGEKRG GAEGSPKPAV YATRKTPSVG SQGDQWYLGY PGDQWSSGFP YSWWKNSVGS ESKHGEGALD QPQHDVRLED LGELHRAARS GDVPGVEHIL APGDTGVDKR DRKKSIQQLV PEYKEKQTPE SLPQNNNPDW HPTNLTLSDE TCQRSKNLKV DDKCPSVSPS MPENQSATKE LGQMNLTERE KMDTGVVLLS GNDTLHDLCQ SQLPENKESK EAEQDSELTS EEEQERLKGC ENKQPQKTSQ EPEMAKDCDR EDIPIYPVLP HVQKSEEMWI EQGKLEWKNQ LKLVINELKQ RFGEIYEKYK IPACPEEEPL LDNSTRGTDV KDIPFNLTNN IPGCEEEDAS EISVSVVFET FPEQKEPSLK NIIHPYYHPY SGSQEHVCQS SSKFHLHENK LDCDNDNKPG IGHIFSTDKN FHNDASTKKA RNPEVVMVEM KEDQEFDLQM TKNMNQNSDS GSTNNYKSLK PKLENLSSLP PDSDRTSEVY LHEELQQDMQ KFKNEVNTLE EEFLALKKED VQLHKDVEEE MEKHRSNSTE LSGTLTDGTT VGNDDDGLNQ QIPRKENGEH DRPADKTSNE KNEVKNQIYP EADFADSMEP SEIASEDCEL SHSVYENFML LIEQLRMEYK DSASLPRIQD TFCLCEHLLK LKNNHCDQLT VKLKQMENMV SVLQNELSET KKTKLQLELQ KIEWEKELYD LRLALKQENE EKRNADMLYN KDSEQLRIKE EECGKVVETK QQLKWNLRRL VKELRTVRNN LDLVVQERND AQKQLSEEQD ARILQDQILT SKQKELEMAR KKMNSEISHR HQKEKDLFHE DCMLQEEIAL LRLEIDTIKN QNKQKEKKYF EDIEAVKEKN DNLQKIIKLN EETLTETILQ YSGQLNNLTA ENKILNSELE NGKQNQERLE IEMESYRCRL AAAVRDCDQS QTARDLKLDF QRTRQEWVRL HDKMKVDMSG LQAKNEILSE KLSNAESKIN SLQIQLHNTR DALGRESLIL ERVQRDLSQT QCQKKETEQM YQIEQSKLKK YIAKQESVEE RLSQLQSENM LLRQQLDDAH KKANSQEKTS STIQDQFHSA AKNLQAESEK QILSLQEKNK ELMDEYNHLK ERMDQCEKEK AGRKIDLTEA QETVPSRCLH LDAENEVLQL QQTLFSMKAI QKQCETLQKN KKQLKQEVVN LKSYMERNML ERGKAEWHKL LIEERARKEI EEKLNEAILT LQKQAAVSHE QLVQLREDNT TSIKTQMELT IKDLESEISR IKTSQADFNK TELERYKELY LEEVKVRESL SNELSRTNEM IAEVSTQLTV EKEQTRSRSL FTAYATRPVL ESPCVGNLND SEGLNRKHIP RKKRSALKDM ESYLLKMQQK LQNDLTAEVA GSSQTGLHRI PQCSSFSSSS LHLLLCSICQ PFFLILQLLL NMNLDPI
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