Doublecortin domain-containing protein 2B (DCDC2B)

About Doublecortin domain-containing protein 2B

Doublecortin domain-containing protein 2B (DCDC2B) is a protein from Homo sapiens identified by UniProt accession A2VCK2, 349 residues long. MolForge cross-references it against 0 known binders and 54 disease associations.

Target properties

Protein name	Doublecortin domain-containing protein 2B
UniProt accession	A2VCK2
Gene	DCDC2B
Organism	Homo sapiens
Length	349 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (54)

Diseases linked to this target (Open Targets).

primary familial polycythemia due to EPO receptor mutation · score 0.09
Blackfan-Diamond anemia · score 0.08
erythrocytosis, familial, 3 · score 0.07
erythrocytosis, familial, 6 · score 0.07
hemolytic anemia due to diphosphoglycerate mutase deficiency · score 0.07
Pyruvate kinase hyperactivity · score 0.07
alpha thalassemia-intellectual disability syndrome type 1 · score 0.06
Alpha-thalassemia - intellectual disability syndrome linked to chromosome 16 · score 0.06
intelligence · score 0.06
erythrocytosis, familial, 4 · score 0.06

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-A2VCK2-F1	alphafold	PREDICTED	67.50	—

Amino-acid sequence (349 residues)

MAGGSPAAKR VVVYRNGDPF FPGSQLVVTQ RRFPTMEAFL CEVTSAVQAP LAVRALYTPC HGHPVTNLAD LKNRGQYVAA GFERFHKLHY LPHRGKDPGG KSCRLQGPPV TRHLCDGAIG RQLPAGAPSY IHVFRNGDLV SPPFSLKLSQ AASQDWETVL KLLTEKVKLQ SGAVCKLCTL EGLPLSAGKE LVTGHYYVAV GEDEFKDLPY LELLVPSPSL PRGCWQPPGS KSRPHRQGAQ GHRAQVTQPS PKEPDRIKPS AFYARPQQTI QPRSKLPTLS FPSGVIGVYG APHRRKETAG ALEVADDEDT QTEEPLDQRA AQIVEEALSL ENQPGAGAAI SASAPALPS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards