About von Willebrand factor A domain-containing protein 8
von Willebrand factor A domain-containing protein 8 (VWA8) is a protein
from Homo sapiens identified by UniProt accession
A3KMH1, 1905 residues long.
MolForge cross-references it against 0 known binders and
84 disease associations.
Target properties
| Protein name | von Willebrand factor A domain-containing protein 8 |
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| UniProt accession | A3KMH1 |
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| Gene | VWA8 |
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| Organism | Homo sapiens |
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| Length | 1905 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (84)
Diseases linked to this target (Open Targets).
- calcium measurement · score 0.47
- mean corpuscular volume · score 0.39
- Orofacial cleft · score 0.38
- Immature Reticulocyte Fraction Measurement · score 0.36
- reticulocyte measurement · score 0.32
- self reported educational attainment · score 0.32
- mathematical ability · score 0.32
- chronotype measurement · score 0.31
- systolic blood pressure · score 0.30
- reticulocyte count · score 0.30
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-A3KMH1-F1 | alphafold | PREDICTED | 78.97 | — |
Amino-acid sequence (1905 residues)
MQSRLLLLGA PGGHGGPASR RMRLLLRQVV QRRPGGDRQR PEVRLLHAGS GADTGDTVNI GDVSYKLKIP KNPELVPQNY ISDSLAQSVV QHLRWIMQKD LLGQDVFLIG PPGPLRRSIA MQYLELTKRE VEYIALSRDT TETDLKQRRE IRAGTAFYID QCAVRAATEG RTLILEGLEK AERNVLPVLN NLLENREMQL EDGRFLMSAE RYDKLLRDHT KKELDSWKIV RVSENFRVIA LGLPVPRYSG NPLDPPLRSR FQARDIYYLP FKDQLKLLYS IGANVSAEKV SQLLSFATTL CSQESSTLGL PDFPLDSLAA AVQILDSFPM MPIKHAIQWL YPYSILLGHE GKMAVEGVLK RFELQDSGSS LLPKEIVKVE KMMENHVSQA SVTIRIADKE VTIKVPAGTR LLSQPCASDR FIQTLSHKQL QAEMMQSHMV KDICLIGGKG CGKTVIAKNF ADTLGYNIEP IMLYQDMTAR DLLQQRYTLP NGDTAWRSSP LVNAALEGKL VLLDGIHRVN AGTLAVLQRL IHDRELSLYD GSRLLREDRY MRLKEELQLS DEQLQKRSIF PIHPSFRIIA LAEPPVIGST AHQWLGPEFL TMFFFHYMKP LVKSEEIQVI KEKVPNVPQE ALDKLLSFTH KLRETQDPTA QSLAASLSTR QLLRISRRLS QYPNENLHSA VTKACLSRFL PSLARSALEK NLADATIEIN TDDNLEPELK DYKCEVTSGT LRIGAVSAPI YNAHEKMKVP DVLFYDNIQH VIVMEDMLKD FLLGEHLLLV GNQGVGKNKI VDRFLHLLNR PREYIQLHRD TTVQTLTLQP SVKDGLIVYE DSPLVKAVKL GHILVVDEAD KAPTNVTCIL KTLVENGEMI LADGRRIVAN SANVNGRENV VVIHPDFRMI VLANRPGFPF LGNDFFGTLG DIFSCHAVDN PKPHSELEML RQYGPNVPEP ILQKLVAAFG ELRSLADQGI INYPYSTREV VNIVKHLQKF PTEGLSSVVR NVFDFDSYNN DMREILINTL HKYGIPIGAK PTSVQLAKEL TLPEQTFMGY WTIGQARSGM QKLLCPVETH HIDIKGPALI NIQEYPIERH EERSLNFTEE CASWRIPLDE INIICDIATS HENEQNTLYV VTCNPASLYF MNMTGKSGFF VDFFDIFPRT ANGVWHPFVT VAPLGSPLKG QVVLHEQQSN VILLLDTTGR ALHRLILPSE KFTSKKPFWW NKEEAETYKM CKEFSHKNWL VFYKEKGNSL TVLDVLEGRT HTISLPINLK TVFLVAEDKW LLVESKTNQK YLLTKPAHIE SEGSGVCQLY VLKEEPPSTG FGVTQETEFS IPHKISSDQL SSEHLSSAVE QKIASPNRIL SDEKNYATIV VGFPDLMSPS EVYSWKRPSS LHKRSGTDTS FYRGKKKRGT PKQSNCVTLL DTNQVVRILP PGEVPLKDIY PKDVTPPQTS GYIEVTDLQS KKLRYIPIPR SESLSPYTTW LSTISDTDAL LAEWDKSGVV TVDMGGHIRL WETGLERLQR SLMEWRNMIG QDDRNMQITI NRDSGEDVSS PKHGKEDPDN MPHVGGNTWA GGTGGRDTAG LGGKGGPYRL DAGHTVYQVS QAEKDAVPEE VKRAAREMGQ RAFQQRLKEI QMSEYDAATY ERFSGAVRRQ VHSLRIILDN LQAKGKERQW LRHQATGELD DAKIIDGLTG EKAIYKRRGE LEPQLGSPQQ KPKRLRLVVD VSGSMYRFNR MDGRLERTME AVCMVMEAFE NYEEKFQYDI VGHSGDGYNI GLVPMNKIPK DNKQRLEILK TMHAHSQFCM SGDHTLEGTE HAIKEIVKEE ADEYFVIVLS DANLSRYGIH PAKFAQILTR DPQVNAFAIF IGSLGDQATR LQRTLPAGRS FVAMDTKDIP QILQQIFTST MLSSV
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