PRAME family member 27 (PRAMEF27)

About PRAME family member 27

PRAME family member 27 (PRAMEF27) is a protein from Homo sapiens identified by UniProt accession A3QJZ7, 478 residues long. MolForge cross-references it against 0 known binders and 102 disease associations.

Target properties

Protein name	PRAME family member 27
UniProt accession	A3QJZ7
Gene	PRAMEF27
Organism	Homo sapiens
Length	478 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (102)

Diseases linked to this target (Open Targets).

azoospermia · score 0.09
partial chromosome Y deletion · score 0.08
spermatogenic failures 50 · score 0.08
spermatogenic failure, X-linked, 2 · score 0.08
spermatogenic failure 25 · score 0.08
spermatogenic failure 63 · score 0.07
isochromosomy Yp · score 0.07
male infertility with teratozoospermia due to single gene mutation · score 0.07
Male infertility with spermatogenesis disorder due to single gene mutation · score 0.07
spermatogenic failure 61 · score 0.07

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-A3QJZ7-F1	alphafold	PREDICTED	83.92	—

Amino-acid sequence (478 residues)

MKMSIRTPPR LLELAGRSLL RDQALAMSTL EELPTELFPP LFMEAFSRRC CEALKLMVQA WPFRRLPLRP LIKMPCLEAF QAVLDGLDAL LTQGVCPRRW KLQVLDLQDV CENFWMVWSE AMARGSFLNA KRNKTPVQDC PRMRGQQPLT VFVELWLKNR TLDEYLTYLL LWVKQRKDLL HLCCKKLKIL GMPFRNIRSI LKMVNLDCIQ EVEVNCKWVL PILTQFTPYL GHMRNLQKLV LSHMDVSRYV SPEQKKEIVT QFTTQFLKLH CLQKLYMNSV SFLEGHLDQL LSCLKTSLKV LTITNCVLLE SDLKHLSQCP SISQLKTLDL SGIRLTNYSL VPLQILLEKV AATLEYLDLD DCGIIDSQVN AILPALSRCF ELNAFSFCGN PISMATLENL LSHTIILKNL CVEVYPAPRE SYGADGTLCW NRFAQIRAEL MNRVRDLRHP KRIFFCIDNC PDCGNRSFYD LEADQYCC

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards