About D-ribitol-5-phosphate cytidylyltransferase
D-ribitol-5-phosphate cytidylyltransferase (CRPPA) is a protein
from Homo sapiens identified by UniProt accession
A4D126, 451 residues long.
MolForge cross-references it against 0 known binders and
117 disease associations.
Target properties
| Protein name | D-ribitol-5-phosphate cytidylyltransferase |
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| UniProt accession | A4D126 |
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| Gene | CRPPA |
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| Organism | Homo sapiens |
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| Length | 451 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (117)
Diseases linked to this target (Open Targets).
- muscular dystrophy-dystroglycanopathy (congenital with brain and eye anomalies), type A, 7 · score 0.78
- autosomal recessive limb-girdle muscular dystrophy type 2U · score 0.69
- Autosomal recessive limb-girdle muscular dystrophy due to ISPD deficiency · score 0.63
- Congenital muscular alpha-dystroglycanopathy with brain and eye anomalies · score 0.55
- limb-girdle muscular dystrophy-dystroglycanopathy, type c1 · score 0.55
- muscular dystrophy-dystroglycanopathy · score 0.41
- muscular dystrophy-dystroglycanopathy, type A · score 0.38
- myopathy caused by variation in CRPPA · score 0.37
- congenital muscular dystrophy without intellectual disability · score 0.37
- muscle-eye-brain disease · score 0.37
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-A4D126-F1 | alphafold | PREDICTED | 87.86 | — |
Amino-acid sequence (451 residues)
MEAGPPGSAR PAEPGPCLSG QRGADHTASA SLQSVAGTEP GRHPQAVAAV LPAGGCGERM GVPTPKQFCP ILERPLISYT LQALERVCWI KDIVVAVTGE NMEVMKSIIQ KYQHKRISLV EAGVTRHRSI FNGLKALAED QINSKLSKPE VVIIHDAVRP FVEEGVLLKV VTAAKEHGAA GAIRPLVSTV VSPSADGCLD YSLERARHRA SEMPQAFLFD VIYEAYQQCS DYDLEFGTEC LQLALKYCCT KAKLVEGSPD LWKVTYKRDL YAAESIIKER ISQEICVVMD TEEDNKHVGH LLEEVLKSEL NHVKVTSEAL GHAGRHLQQI ILDQCYNFVC VNVTTSDFQE TQKLLSMLEE SSLCILYPVV VVSVHFLDFK LVPPSQKMEN LMQIREFAKE VKERNILLYG LLISYPQDDQ KLQESLRQGA IIIASLIKER NSGLIGQLLI A
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