About Protein FAM221A
Protein FAM221A (FAM221A) is a protein
from Homo sapiens identified by UniProt accession
A4D161, 298 residues long.
MolForge cross-references it against 0 known binders and
31 disease associations.
Target properties
| Protein name | Protein FAM221A |
|---|
| UniProt accession | A4D161 |
|---|
| Gene | FAM221A |
|---|
| Organism | Homo sapiens |
|---|
| Length | 298 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (31)
Diseases linked to this target (Open Targets).
- chronotype measurement · score 0.10
- schizophrenia · score 0.09
- vital capacity · score 0.06
- type 2 diabetes mellitus · score 0.06
- body height · score 0.05
- alkaline phosphatase measurement · score 0.04
- Congenital dyserythropoietic anemia type IV · score 0.04
- congenital dyserythropoietic anemia type 4 · score 0.04
- PHF-tau measurement · score 0.03
- dehydrated hereditary stomatocytosis · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-A4D161-F1 | alphafold | PREDICTED | 83.48 | — |
Amino-acid sequence (298 residues)
MERLTLPLGG AAAVDEYLEY RRIVGEDDGG KLFTPEEYEE YKRKVLPLRL QNRLFVSWRS PTGMDCKLVG PETLCFCTHR YKQHKTDLEA IPQQCPIDLP CQVTGCQCRA YLYVPLNGSQ PIRCRCKHFA DQHSAAPGFT CNTCSKCSGF HSCFTCACGQ PAYAHDTVVE TKQERLAQEK PVGQDIPYAA MGGLTGFSSL AEGYMRLDDS GIGVPSVEFL ESPITAVDSP FLKAFQASSS SSPETLTDVG TSSQVSSLRR PEEDDMAFFE RRYQERMKME KAAKWKGKAP LPSATKPS
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