About Dual specificity protein phosphatase CDC14C
Dual specificity protein phosphatase CDC14C (CDC14C) is a protein
from Homo sapiens identified by UniProt accession
A4D256, 447 residues long.
MolForge cross-references it against 0 known binders and
22 disease associations.
Target properties
| Protein name | Dual specificity protein phosphatase CDC14C |
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| UniProt accession | A4D256 |
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| Gene | CDC14C |
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| Organism | Homo sapiens |
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| Length | 447 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (22)
Diseases linked to this target (Open Targets).
- type 2 diabetes mellitus · score 0.28
- self reported educational attainment · score 0.25
- cognitive decline measurement · score 0.18
- metabolite measurement · score 0.18
- CACH syndrome · score 0.04
- hypergonadotropic hypogonadism-cataract syndrome · score 0.04
- Hypergonadotropic hypogonadism - cataract syndrome · score 0.04
- lattice corneal dystrophy type I · score 0.03
- ichthyosis-intellectual disability-dwarfism-renal impairment syndrome · score 0.03
- Familial ocular anterior segment mesenchymal dysgenesis · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-A4D256-F1 | alphafold | PREDICTED | 85.69 | — |
Amino-acid sequence (447 residues)
MRSSTLQDPR RRDPQDDVYV DITDRLRFAI LYSRPKSASN VHYFSIDNEL EYENFSEDFG PLNLAMVYRY CCKINKKLKS ITMLRKKIVH FTGSDQRKQA NAAFLVGCYM VIYLGRTPEA AYRILIFGDT PYIPFRDAAY GSCNFYITLL DCFHAVKKAM QYGFLNFNSF NLDEYEHYEK AENGDLNWII PDRFIAFCGP HSRARLESGY HQHSPETYIQ YFKNHNVTTI IRLNKRMYDA KRFTDAGFDH HDLFFADGST PTDAIVKRFL DICENAEGAI AVHCKAGLGR TGTLIACYIM KHYRMTAAET IAWVRICRPG LVIGPQQQFL VMKQTSLWLE GDYFRQRLKG QENGQHRAAF SKLLSGVDDI SINGVENQDQ QEPKPYSDDD EINGVTQGDR SRALKRRRQS KTNDILLPSP LAVLTFTLCS VVIWWIVCDY ILPILLF
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