About SH3 domain-containing protein 21
SH3 domain-containing protein 21 (SH3D21) is a protein
from Homo sapiens identified by UniProt accession
A4FU49, 640 residues long.
MolForge cross-references it against 0 known binders and
30 disease associations.
Target properties
| Protein name | SH3 domain-containing protein 21 |
|---|
| UniProt accession | A4FU49 |
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| Gene | SH3D21 |
|---|
| Organism | Homo sapiens |
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| Length | 640 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (30)
Diseases linked to this target (Open Targets).
- reticulocyte count · score 0.36
- platelet count · score 0.34
- body height · score 0.34
- neurodegenerative disease · score 0.33
- Immature Reticulocyte Fraction Measurement · score 0.25
- platelet crit · score 0.25
- reticulocyte measurement · score 0.24
- appendicular lean mass · score 0.23
- FEV/FVC ratio · score 0.23
- vital capacity · score 0.11
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-A4FU49-F1 | alphafold | PREDICTED | 52.56 | — |
Amino-acid sequence (640 residues)
MVQSELQLQP RAGGRAEAAS WGDRGNDKGG LGNPDMPSVS PGPQRPPKLS SLAYDSPPDY LQTVSHPEVY RVLFDYQPEA PDELALRRGD VVKVLSKTTE DKGWWEGECQ GRRGVFPDNF VLPPPPIKKL VPRKVVSRES APIKEPKKLM PKTSLPTVKK LATATTGPSK AKTSRTPSRD SQKLTSRDSG PNGGFQSGGS YHPGRKRSKT QTPQQRSVSS QEEEHSSPVK APSVKRTPMP DKTATPERPP APENAPSSKK IPAPDKVPSP EKTLTLGDKA SIPGNSTSGK IPAPDKVPTP EKMVTPEDKA SIPENSIIPE ETLTVDKPST PERVFSVEES PALEAPPMDK VPNPKMAPLG DEAPTLEKVL TPELSEEEVS TRDDIQFHHF SSEEALQKVK YFVAKEDPSS QEEAHTPEAP PPQPPSSERC LGEMKCTLVR GDSSPRQAEL KSGPASRPAL EKPHPHEEAT TLPEEAPSND ERTPEEEAPP NEQRPLREEV LPKEGVASKE EVTLKEELPP KEEVAPKEEV PPIERAFAQK TRPIKPPPDS QETLALPSLV PQNYTENKNE GVDVTSLRGE VESLRRALEL MEVQLERKLT DIWEELKSEK EQRRRLEVQV MQGTQKSQTP RVIHTQTQTY
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