About KRAB domain-containing protein 3
KRAB domain-containing protein 3 (KRABD3) is a protein
from Homo sapiens identified by UniProt accession
A5PL33, 1030 residues long.
MolForge cross-references it against 0 known binders and
19 disease associations.
Target properties
| Protein name | KRAB domain-containing protein 3 |
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| UniProt accession | A5PL33 |
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| Gene | KRABD3 |
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| Organism | Homo sapiens |
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| Length | 1030 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (19)
Diseases linked to this target (Open Targets).
- platelet count · score 0.42
- mean corpuscular volume · score 0.39
- mosaic loss of chromosome Y measurement · score 0.38
- mean corpuscular hemoglobin concentration · score 0.37
- platelet crit · score 0.36
- neurodegenerative disease · score 0.29
- mean reticulocyte volume · score 0.28
- reticulocyte count · score 0.21
- reticulocyte measurement · score 0.09
- Immature Reticulocyte Fraction Measurement · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-A5PL33-F1 | alphafold | PREDICTED | 42.28 | — |
Amino-acid sequence (1030 residues)
MRENYETLVS VGTAELLPLS AFLSPSEPGR AVGGGSHADE GQEPAGCGDP QGGQPRHSLH LTALVQLVKE IPEFLFGEVK GAMDSPESES RGASLDGERA SPEAAAAREP CPLRGLLSCL PDGPTSQPHL ATTPTDSSCS SGPTGDGVQG SPLPIKTADK PWPTRKEGPG ALGGEPSPPT HSPSRRKSHR GQERGTSEAG ISPGNSPLQG LINCLKEILV PGPRHPETSP SFLPPLPSLG TSRLTRADLG PGSPPWAVKT EAVSGDCPLQ GLLHCLKELP EAQDRHPSPS GVGNRRLQEN PGAWKRGSGG PGYLLTPPPH PDLGAGGLLS VKMENSWVQS PPGPASCQPG RQPLSPSATG DTRGVPQPSW GPEAQAASAS SSPLEALEAC LKGIPPNGSS PSQLPPTSCS QNPQPGDSRS QKPELQPHRS HSEEATREPV LPLGLQSCVR DGPSRPLAPR GTPTSFSSSS STDWDLDFGS PVGNQGQHPG KGSPPGSSPL QGLENCLKEI PVPVLRPAWP CSSAADRGPR RAEPRNWTAD KEGLRAEACE SARLGQGRGE APTRSLHLVS PQVFTSSCVP ACHQRGFKDP GATRPGVWRW LPEGSAPKPS PLHCLESALR GILPVRPLRF ACVGGPSPSP SPGSSSSFSG SEGEDPRPEP DLWKPLPQER DRLPSCKPPV PLSPCPGGTP AGSSGGSPGE DPRRTEPRYC SGLGAGTAQD PCPVSQLEKR PRVSEASRGL ELGHGRPRVA AKTHERLLPQ GPPELPSESP PPELPPPEAA PPVLPASSLQ PPCHCGKPLQ QELHSLGAAL AEKLDRLATA LAGLAQEVAT MRTQVNRLGR RPQGPGPMGQ ASWMWTLPRG PRWAHGPGHR HLPYWRQKGP TRPKPKILRG QGESCRAGDL QGLSRGTARR ARPLPPDAPP AEPPGLHCSS SQQLLSSTPS CHAAPPAHPL LAHTGGHQSP LPPLVPAALP LQGASPPAAS ADADVPTSGV APDGIPERPK EPSSLLGGVQ RALQEELWGG EHRDPRWGAH
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