About Regulator of G-protein signaling protein-like
Regulator of G-protein signaling protein-like (RGSL1) is a protein
from Homo sapiens identified by UniProt accession
A5PLK6, 1076 residues long.
MolForge cross-references it against 0 known binders and
25 disease associations.
Target properties
| Protein name | Regulator of G-protein signaling protein-like |
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| UniProt accession | A5PLK6 |
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| Gene | RGSL1 |
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| Organism | Homo sapiens |
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| Length | 1076 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (25)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.41
- breast adenocarcinoma · score 0.23
- glioblastoma multiforme · score 0.22
- Red cell distribution width · score 0.16
- metabolite measurement · score 0.15
- high density lipoprotein cholesterol measurement · score 0.11
- medulloblastoma · score 0.11
- lymphocyte count · score 0.10
- apolipoprotein A 1 measurement · score 0.10
- total blood protein measurement · score 0.10
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-A5PLK6-F1 | alphafold | PREDICTED | 67.16 | — |
Amino-acid sequence (1076 residues)
MSSAEIIGST NLIILLEDEV FADFFNTFLS LPVFGQTPFY TVENSQWSLW PEIPCNLIAK YKGLLTWLEK CRLPFFCKTN LCFHYILCQE FISFIKSPEG GEELVDFWIL AENILSIDEM DLEVRDYYLS LLLMLRATHL QEGSRVVTLC NMNIKSLLNL SIWHPNQSTT RREILSHMQK VALFKLQSYW LPNFYTHTKM TMAKEEACHG LMQEYETRLY SVCYTHIGGL PLNMSIKKCH HFQKRYSSRK AKRKMWQLVD PDSWSLEMDL KPDAIGMPLQ ETCPQEKVVI QMPSLKMASS KETRISSLEK DMHYAKISSM ENKAKSHLHM EAPFETKVST HLRTVIPIVN HSSKMTIQKA IKQSFSLGYI HLALCADACA GNPFRDHLKK LNLKVEIQLL DLWQDLQHFL SVLLNNKKNG NAIFRHLLGD RICELYLNEQ IGPCLPLKSQ TIQGLKELLP SGDVIPWIPK AQKEICKMLS PWYDEFLDEE DYWFLLFTTQ NRFISSRQHK REFIGKEENI LLYKRIQQSL ELSQALADMK EMDYRQWRKI ATEDLKQGGS LQVELTSPVF LTDITKMSFE ELCYKNPKMA IQKISDDYKI YCEKAPKIDF KMEIIKETKT VSRSNRKMSL LKRTLVRKPS MRPRNLTEVL LNTQHLEFFR EFLKERKAKI PLQFLTAVQK ISIETNEKIC KSLIENVIKT FFQGQLSPEE MLQCDAPIIK EIASMRHVTT STLLTLQGHV MKSIEEKWFK DYQDLFPPHH QEVEVQSEVQ ISSRKPSKIV STYLQESQKK GWMRMISFIR SFCKYRRFML NPSKRQEFED YLHQEMQNSK ENFTTAHNTS GRSAPPSTNV RSADQENGEI TLVKRRIFGH RIITVNFAIN DLYFFSEMEK FNDLVSSAHM LQVNRAYNEN DVILMRSKMN IIQKLFLNSD IPPKLRVNVP EFQKDAILAA ITEGYLDRSV FHGAIMSVFP VVMYFWKRFC FWKATRSYLQ YRGKKFKDRK SPPKSTDKYP FSSGGDNAIL RFTLLRGIEW LQPQREAISS VQNSSSSKLT QPRLVVSAMQ LHPVQGQKLS YIKKEK
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