About Ankyrin repeat domain-containing protein 34B
Ankyrin repeat domain-containing protein 34B (ANKRD34B) is a protein
from Homo sapiens identified by UniProt accession
A5PLL1, 514 residues long.
MolForge cross-references it against 0 known binders and
17 disease associations.
Target properties
| Protein name | Ankyrin repeat domain-containing protein 34B |
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| UniProt accession | A5PLL1 |
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| Gene | ANKRD34B |
|---|
| Organism | Homo sapiens |
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| Length | 514 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (17)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.35
- systolic blood pressure · score 0.29
- self reported educational attainment · score 0.29
- metabolite measurement · score 0.16
- breast carcinoma · score 0.04
- psoriasis · score 0.03
- Sepsis · score 0.02
- heel bone mineral density · score 0.02
- non-small cell lung carcinoma · score 0.02
- Down syndrome · score 0.02
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-A5PLL1-F1 | alphafold | PREDICTED | 55.24 | — |
Amino-acid sequence (514 residues)
MDEGMEISSE GNSLIKAVHQ SRLRLTRLLL EGGAYINESN DRGETPLMIA CKTKHVDHQS VSKAKMVKYL LENNADPNIQ DKSGKTALMH ACLEKAGPEV VSLLLKSGAD LSLQDHSSYS ALVYAINSED TETLKVLLSA CKAKGKEVII ITTAKLPCGK HTTKQYLNMP PVDIDGCHSP ATCTTPSEID IKTASSPLSH SSETELTLFG FKDLELAGSN DDTWDPGSPV RKPALAPKGP KLPHAPPWVK SPPLLMHQNR VASLQEELQD ITPEEELSYK TNGLALSKRF ITRHQSIDVK DTAHLLRAFD QASSRKMSYD EINCQSYLSE GNQQCIEVPV DQDPDSNQTI FASTLRSIVQ KRNLGANHYS SDSQLSAGLT PPTSEDGKAL IGKKKILSPS PSQLSESKEL LENIPPGPLS RRNHAVLERR GSGAFPLDHS VTQTRQGFLP PLNVNSHPPI SDINVNNKIC SLLSCGQKVL MPTVPIFPKE FKSKKMLLRR QSLQTEQIKQ LVNF
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