About Protein FAM149A
Protein FAM149A (FAM149A) is a protein
from Homo sapiens identified by UniProt accession
A5PLN7, 773 residues long.
MolForge cross-references it against 0 known binders and
37 disease associations.
Target properties
| Protein name | Protein FAM149A |
|---|
| UniProt accession | A5PLN7 |
|---|
| Gene | FAM149A |
|---|
| Organism | Homo sapiens |
|---|
| Length | 773 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (37)
Diseases linked to this target (Open Targets).
- hypothyroidism · score 0.10
- Hashimoto's thyroiditis · score 0.09
- Thyroid preparation use measurement · score 0.06
- autoimmune thyroid disease · score 0.06
- drug use measurement · score 0.04
- thyroid disease · score 0.04
- venous thromboembolism · score 0.03
- myxedema · score 0.03
- partial thromboplastin time · score 0.02
- blood protein measurement · score 0.02
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-A5PLN7-F1 | alphafold | PREDICTED | 49.22 | — |
Amino-acid sequence (773 residues)
MKAAVLDLGS LLAKLFETST APPAGPSSRP SGGAAAAGSG GSRAGTPLGT APTLLRALAP DSPSASRRSP APLLSSPYSR GSAASRAAGA VGTLLSWPSS PRAGKAPPQP PTPSGGGCSP ARLVVPARPP SGPGGVWAAL PRNPLQPGPG ERELGACVAP GAGPRTLFLT LPDIGEEGAS DGDSGDGEAR GLSEGRRRHG FTVRSKDSLP THFTRNVQKA IDKYTCKSLS SFSSSGSHTP TGAHTSWSGS ATQSSTTGSS TERGSVYSWR DDEFDEASSQ SVQRLLWEVE EMLFEGKVNP QTQSLLAECG EWTRRSLHLR VLGRQLILPT DKGVQHFQGS TPASAVHRPP LSACGHSSNI RELCISGSQI VPAALSASAL PGPDDTGVAD LTARSSLEEE VYHVDGKIEE YFAFDRKEDD DECLEQKPAQ PGRKWRKLGL PPVSPRDCVK DAVAAEVFDH VWTNMVELLE ELIRKHWETT LTEGKKQRET LKVAGNRFPH VLVPHAHADG ASGPPSGHAE AHGISLASRL NPPQIHHFSS SFYSDMNGVM TIQAKPLQRR PAYFADRTQN EKEDKASGGG AGALSSAPHR LGRASDTHGL SPSAKKTPVP WRLPSLASDS QRLKTPNIYS DEVLRGTKLP TGVDHMASPL VQTSRSRFPP LVTETRGQNT AVPGCRLVSY RGRHLQNRVL SAMPDGTERS RLRERTATLE RLSRPSTTHT FRQSDTPRKS SLTQMEFAAH TWTGQSILTG SQYVPKSFQR TTLTFKRRFQ VTS
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