5-hydroxytryptamine receptor 3E (HTR3E)

About 5-hydroxytryptamine receptor 3E

5-hydroxytryptamine receptor 3E (HTR3E) is a protein from Homo sapiens identified by UniProt accession A5X5Y0, 456 residues long. MolForge cross-references it against 0 known binders and 59 disease associations.

Target properties

Protein name	5-hydroxytryptamine receptor 3E
UniProt accession	A5X5Y0
Gene	HTR3E
Organism	Homo sapiens
Length	456 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (59)

Diseases linked to this target (Open Targets).

schizophrenia · score 0.59
post operative nausea and vomiting · score 0.57
irritable bowel syndrome · score 0.54
schizoaffective disorder · score 0.50
type 2 diabetes mellitus · score 0.46
Nausea and vomiting · score 0.46
psychosis · score 0.46
Chemotherapy-induced nausea and vomiting · score 0.44
cancer · score 0.44
Vomiting · score 0.43

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-A5X5Y0-F1	alphafold	PREDICTED	80.83	—

Amino-acid sequence (456 residues)

MEGSWFHRKR FSFYLLLGFL LQGRGVTFTI NCSGFGQHGA DPTALNSVFN RKPFRPVTNI SVPTQVNISF AMSAILDVNE QLHLLSSFLW LEMVWDNPFI SWNPEECEGI TKMSMAAKNL WLPDIFIIEL MDVDKTPKGL TAYVSNEGRI RYKKPMKVDS ICNLDIFYFP FDQQNCTLTF SSFLYTVDSM LLDMEKEVWE ITDASRNILQ THGEWELLGL SKATAKLSRG GNLYDQIVFY VAIRRRPSLY VINLLVPSGF LVAIDALSFY LPVKSGNRVP FKITLLLGYN VFLLMMSDLL PTSGTPLIGV YFALCLSLMV GSLLETIFIT HLLHVATTQP PPLPRWLHSL LLHCNSPGRC CPTAPQKENK GPGLTPTHLP GVKEPEVSAG QMPGPAEAEL TGGSEWTRAQ REHEAQKQHS VELWLQFSHA MDAMLFRLYL LFMASSIITV ICLWNT

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards