Rho guanine nucleotide exchange factor 35 (ARHGEF35)

About Rho guanine nucleotide exchange factor 35

Rho guanine nucleotide exchange factor 35 (ARHGEF35) is a protein from Homo sapiens identified by UniProt accession A5YM69, 484 residues long. MolForge cross-references it against 0 known binders and 5 disease associations.

Target properties

Protein name	Rho guanine nucleotide exchange factor 35
UniProt accession	A5YM69
Gene	ARHGEF35
Organism	Homo sapiens
Length	484 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (5)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.23
breast adenocarcinoma · score 0.18
glioblastoma multiforme · score 0.11
pancreatic adenocarcinoma · score 0.04
diet measurement · score 0.02

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-A5YM69-F1	alphafold	PREDICTED	44.55	—

Amino-acid sequence (484 residues)

MEAEEAQHGA SPPISAIEEF SIIPEAPMRS SQVSALGLEA QEDEDPSYKW REEHRLSATQ QSELRDVCDY AIETMPSFPK EGSADVEPNQ ESLVAEACDT PEHWEAVPQS LAGRQARTLA PPELWACPIQ SEHLDMAPFS SDLGSEEEEV EFWPGLTSLT LGSGQAEEEE ETSSDNSGQT RYYSPCEEHP AETNQNEGAE SGTIRQGEEL PSEELQESQG LLHPQEVQVL EEQGQQEAGF RGEGTLREDV CADGLLGEEQ MIEQVNDEKG EQKQKQEQVQ DVMLGRQGER MGLTGEPEGL NDGEWEQEDM ERKAQGQGGP EQGEERKREL QVPEENRADS QDEKSQTFLG KSEEVTGKQE DHGIKEKGVP VSGQEAKEPE SWDGGRLGAV GRARSREEEN EHHGPSMPAL IAPEDSPHCD LFPGASYLVT QIPGTQTESR AEELSPAALS PLLEPIRCSH QPISLLGSFL TEESPDKEKL LSVL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards