About Carnosine synthase 1
Carnosine synthase 1 (CARNS1) is a protein
from Homo sapiens identified by UniProt accession
A5YM72, 827 residues long.
MolForge cross-references it against 0 known binders and
74 disease associations.
Target properties
| Protein name | Carnosine synthase 1 |
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| UniProt accession | A5YM72 |
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| Gene | CARNS1 |
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| Organism | Homo sapiens |
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| Length | 827 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
|---|
Disease associations (74)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.33
- mean corpuscular volume · score 0.25
- mean reticulocyte volume · score 0.19
- mean corpuscular hemoglobin concentration · score 0.18
- mean corpuscular hemoglobin · score 0.13
- Red cell distribution width · score 0.11
- red blood cell density measurement · score 0.11
- grip strength measurement · score 0.11
- cutaneous melanoma · score 0.10
- erythrocyte count · score 0.09
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-A5YM72-F1 | alphafold | PREDICTED | 88.75 | — |
Amino-acid sequence (827 residues)
MLLCLSPAWL MKVPAPGQPG EAALLVSKAV SFHPGGLTFL DDFVPPRRAT YFLAGLGLGP GRGREAAELA RDLTCPTGAS AELARLLEDR LLTRQLLAQQ GGVAVPATLA FTYKPPGLLR GGDASLGLRL VELSGKEGQE TLVKEEVEAF LRSEALGDIL QVAVKLSGWR WRGRQAWRLH PRAELGAVVD TVLALLEKLE EEESVLVEAV YPPAQLPCSD GPSPGPGLAV RICAVVCRTQ GDRPLLSKVV CGVGRGDRPL RHHNSLPRTL EVALAQCGLG EEAQVAAVRQ RVKAAAEAAL AAVLALEAGL SAEQRGGRRA HTDFLGVDFA LTAAGGVLTP VALELNGGLC LEACGALEGL WAAPRLGPAA DEAVAAPLVE TMLRRSARCL MEGKQLLVVG AGGVSKKFVW EAARDYGLQL HLVESDPNHF ASQLVQTFIH FDMTEHRRDE ENARLLAELV RARGLKLDGC FSYWDDCLVL TALLCQELGL PCSSPAAMRL AKQKSLTQLH LLHHHGPPWP APSLHAVPCC PLESEADVER AVHQVPLPGV MKLEFGAGAV GVRLVEDAPQ CHEHFSRITR DLQGEADHPG IGLGWGNAML LMEFVEGTEH DVDLVLFGGR LLAAFVSDNG PTRLPGFTET AACMPTGLAP EQEAQMVQAA FRCCLGCGLL DGVFNVELKL TGAGPRLIEI NPRMGGFYLR DWILELYGVD LLLAAVMVAC GLRPALPTRP RARGHLVGVM CLVSQHLQAL SSTASRETLQ ALHDRGLLRL NLLEEALVPG EYEEPYCSVA CAGPSPTEAR LRLLGLCQGL GIDGPSYPVA HFLSHFK
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