About Protein FAM221B
Protein FAM221B (FAM221B) is a protein
from Homo sapiens identified by UniProt accession
A6H8Z2, 402 residues long.
MolForge cross-references it against 0 known binders and
11 disease associations.
Target properties
| Protein name | Protein FAM221B |
|---|
| UniProt accession | A6H8Z2 |
|---|
| Gene | FAM221B |
|---|
| Organism | Homo sapiens |
|---|
| Length | 402 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (11)
Diseases linked to this target (Open Targets).
- serum gamma-glutamyl transferase measurement · score 0.18
- hip circumference · score 0.08
- blood protein measurement · score 0.08
- hemojuvelin measurement · score 0.06
- cortical surface area measurement · score 0.05
- heel bone mineral density · score 0.04
- body height · score 0.03
- Red cell distribution width · score 0.02
- appendicular lean mass · score 0.02
- lymphocyte count · score 0.02
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-A6H8Z2-F1 | alphafold | PREDICTED | 63.72 | — |
Amino-acid sequence (402 residues)
MEAHEIIEEP HITMDAEKHP PSKDPSAEDL QENHISESFL KPSTSETPLE PHTSESPLVP SPSQIPLEAH SPETHQEPSI SETPSETPTY EASLDSPISV VPEKHLTLPP QSRDYVCLSS SDTLKEDLSS ESSSNEVPWT RRSTHLSESE SLPEHCLSGP SSQVQVDTTE KQEEEAGEVE KGVDASDSTA HTAQPGHQLG NTARPVFPAR QTELVEVAKA MHREEFGAQV NNLFQWEKDA ALNAIQTGLY IGWRCPHYLW DCFRIGDESR CFCGHLLREH RIISDISVPC KVSQCRCFMF CFIPSRPEEV GEFWLKRRAT FDPKAWRAQC RCKHSHEEHA ATGPHPCRHH GCCCGCFESN FLCAACDRRW EEHETFFDTQ KTRQRGGRPR GTDTVSNWHR PL
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