About Coiled-coil domain-containing protein 88B
Coiled-coil domain-containing protein 88B (CCDC88B) is a protein
from Homo sapiens identified by UniProt accession
A6NC98, 1476 residues long.
MolForge cross-references it against 0 known binders and
132 disease associations.
Target properties
| Protein name | Coiled-coil domain-containing protein 88B |
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| UniProt accession | A6NC98 |
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| Gene | CCDC88B |
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| Organism | Homo sapiens |
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| Length | 1476 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (132)
Diseases linked to this target (Open Targets).
- urate measurement · score 0.31
- reticulocyte measurement · score 0.26
- Immature Reticulocyte Fraction Measurement · score 0.25
- primary biliary cirrhosis · score 0.25
- psoriasis · score 0.25
- basal cell carcinoma · score 0.24
- sarcoidosis · score 0.23
- type 2 diabetes mellitus · score 0.23
- type 1 diabetes mellitus · score 0.23
- Thyroid preparation use measurement · score 0.23
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-A6NC98-F1 | alphafold | PREDICTED | 69.05 | — |
Amino-acid sequence (1476 residues)
MEGGKGPRLR DFLSGSLATW ALGLAGLVGE AEDSEGEEEE EEEEPPLWLE KRFLRLSDGA LLLRVLGIIA PSSRGGPRML RGLDGPAAWR VWNLNHLWGR LRDFYQEELQ LLILSPPPDL QTLGFDPLSE EAVEQLEGVL RLLLGASVQC EHRELFIRHI QGLSLEVQSE LAAAIQEVTQ PGAGVVLALS GPDPGELAPA ELEMLSRSLM GTLSKLARER DLGAQRLAEL LLEREPLCLR PEAPSRAPAE GPSHHLALQL ANAKAQLRRL RQELEEKAEL LLDSQAEVQG LEAEIRRLRQ EAQALSGQAK RAELYREEAE ALRERAGRLP RLQEELRRCR ERLQAAEAYK SQLEEERVLS GVLEASKALL EEQLEAARER CARLHETQRE NLLLRTRLGE AHAELDSLRH QVDQLAEENV ELELELQRSL EPPPGSPGEA PLAGAAPSLQ DEVREAEAGR LRTLERENRE LRGLLQVLQG QPGGQHPLLE APREDPVLPV LEEAPQTPVA FDHSPQGLVQ KARDGGPQAL DLAPPALDSV LEASAECPQA PDSDPQEAES PLQAAAMDPQ ASDWSPQESG SPVETQESPE KAGRRSSLQS PASVAPPQGP GTKIQAPQLL GGETEGREAP QGELVPEAWG LRQEGPEHKP GPSEPSSVQL EEQEGPNQGL DLATGQAEAR EHDQRLEGTV RDPAWQKPQQ KSEGALEVQV WEGPIPGESL ASGVAEQEAL REEVAQLRRK AEALGDELEA QARKLEAQNT EAARLSKELA QARRAEAEAH REAEAQAWEQ ARLREAVEAA GQELESASQE REALVEALAA AGRERRQWER EGSRLRAQSE AAEERMQVLE SEGRQHLEEA ERERREKEAL QAELEKAVVR GKELGDRLEH LQRELEQAAL ERQEFLREKE SQHQRYQGLE QRLEAELQAA ATSKEEALME LKTRALQLEE ELFQLRQGPA GLGPKKRAEP QLVETQNVRL IEVERSNAML VAEKAALQGQ LQHLEGQLGS LQGRAQELLL QSQRAQEHSS RLQAEKSVLE IQGQELHRKL EVLEEEVRAA RQSQEETRGQ QQALLRDHKA LAQLQRRQEA ELEGLLVRHR DLKANMRALE LAHRELQGRH EQLQAQRASV EAQEVALLAE RERLMQDGHR QRGLEEELRR LQSEHDRAQM LLAELSRERG ELQGERGELR GRLARLELER AQLEMQSQQL RESNQQLDLS ACRLTTQCEL LTQLRSAQEE ENRQLLAEVQ ALSRENRELL ERSLESRDHL HREQREYLDQ LNALRREKQK LVEKIMDQYR VLEPVPLPRT KKGSWLADKV KRLMRPRREG GPPGGLRLGA DGAGSTESLG GPPETELPEG READGTGSPS PAPMRRAQSS LCLRDETLAG GQRRKLSSRF PVGRSSESFS PGDTPRQRFR QRHPGPLGAP VSHSKGPGVG WENSAETLQE HETDANREGP EVQEPEKRPL TPSLSQ
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