Geminin coiled-coil domain-containing protein 1 (GMNC)

About Geminin coiled-coil domain-containing protein 1

Geminin coiled-coil domain-containing protein 1 (GMNC) is a protein from Homo sapiens identified by UniProt accession A6NCL1, 334 residues long. MolForge cross-references it against 0 known binders and 49 disease associations.

Target properties

Protein name	Geminin coiled-coil domain-containing protein 1
UniProt accession	A6NCL1
Gene	GMNC
Organism	Homo sapiens
Length	334 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (49)

Diseases linked to this target (Open Targets).

neuroimaging measurement · score 0.40
brain volume measurement · score 0.40
cortical surface area measurement · score 0.39
white matter microstructure measurement · score 0.37
cortical thickness · score 0.37
brain measurement · score 0.36
thalamus volume · score 0.34
body height · score 0.29
ovarian serous carcinoma · score 0.28
intracranial volume measurement · score 0.26

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-A6NCL1-F1	alphafold	PREDICTED	59.52	—

Amino-acid sequence (334 residues)

MNTILPCQDQ YFVGGQSYNC PYSTTTSESS VDVSTETWVS FWAAGLLDNR ELQQAPQAQE SFSDSNFPLP DLCSWEEAQL SSQLYRNKQL QDTLVQKEEE LARLHEENNH LRQYLNSALV KCLEEKAKKL LSSDEFSKAY GKFRKGKRKS KEQRYSPAEI PHPKNAKRNL SSEFANCEEQ AGPPVDPWVL QTLGLKDLDT IDDTSSANYS ALASHPRRVA STFSQFPDDA VDYKNIPRED MPIDYRGDRT TPLHSTATHG EDFHILSQLS NPPVGLKTLP YYTAHVSPNK TEMAFSTSLS PHCNVKTHSF HQGQAFVRRD EEGGWKFTWV PKQS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards