About Ankyrin repeat domain-containing protein 33B
Ankyrin repeat domain-containing protein 33B (ANKRD33B) is a protein
from Homo sapiens identified by UniProt accession
A6NCL7, 494 residues long.
MolForge cross-references it against 0 known binders and
35 disease associations.
Target properties
| Protein name | Ankyrin repeat domain-containing protein 33B |
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| UniProt accession | A6NCL7 |
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| Gene | ANKRD33B |
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| Organism | Homo sapiens |
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| Length | 494 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (35)
Diseases linked to this target (Open Targets).
- eosinophil count · score 0.50
- eosinophil percentage of leukocytes · score 0.45
- total blood protein measurement · score 0.42
- skin disease · score 0.42
- radiation-induced disorder · score 0.42
- serum non-albumin protein measurement · score 0.33
- subcutaneous tissue disorder · score 0.33
- actinic keratosis · score 0.33
- eosinophil percentage of granulocytes · score 0.32
- sum of eosinophil and basophil counts · score 0.32
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-A6NCL7-F1 | alphafold | PREDICTED | 67.05 | — |
Amino-acid sequence (494 residues)
MVLLAGTGPE GGGARCMTPP PPSPPRGAQV EEDPADYEEF EDFSSLPDTR SIASDDSFYP FEDEEEHGVE SAESVPEGVP ESVPETATLL RAACANNVGL LRTLVRRGVS VEEAQETDRN GRTGLIVACY HGFVDTVVAL AECPHVDVNW QDSEGNTALI TAAQAGHAII TNYLLNYFPG LDLERRNAFG FTALMKAAMQ GRTDCIRALM LAGADVHARD PRRGMSPQEW ATYTGRVDAV RLMQRLLERP CPEQFWEKYR PELPPPPEAA RKPAGSKNCL QRLTDCVLSV LTPRSVRGPE DGGVLDHMVR MTTSLYSPAV AIVCQTVCPE SPPSVGKRRL AVQEILAARA ARGPQAQEED EVGGAGQRGR TGQEDADSRE GSPRAGLPPA LGSRGPAAPA PRKASLLPLQ RLRRRSVRPG VVVPRVRVSK APAPTFQPER PARKGSTKDS GHLQIPKWRY KEAKEEKRKA EEAEKKRQAE AQKERRTAPW KKRT
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