About Aspartate dehydrogenase domain-containing protein
Aspartate dehydrogenase domain-containing protein (ASPDH) is a protein
from Homo sapiens identified by UniProt accession
A6ND91, 283 residues long.
MolForge cross-references it against 0 known binders and
11 disease associations.
Target properties
| Protein name | Aspartate dehydrogenase domain-containing protein |
|---|
| UniProt accession | A6ND91 |
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| Gene | ASPDH |
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| Organism | Homo sapiens |
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| Length | 283 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (11)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.27
- erythrocyte count · score 0.04
- hemoglobin measurement · score 0.04
- hematocrit · score 0.04
- atrial flutter · score 0.03
- atrial fibrillation · score 0.03
- cardiac arrhythmia · score 0.02
- chronic obstructive pulmonary disease · score 0.02
- hepatocellular carcinoma · score 0.01
- Crohn's disease · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-A6ND91-F1 | alphafold | PREDICTED | 93.67 | — |
Amino-acid sequence (283 residues)
MADRGPWRVG VVGYGRLGQS LVSRLLAQGP ELGLELVFVW NRDPGRMAGS VPPSLQLQNL AALGERRPDL VVEVAHPKII HESGAQILRH ANLLVGSPSA LSDQTTERQL LEASQHWDHA VFVARGALWG AEDIRRLDAA GGLRSLRVTM ATHPDGFRLE GPLAAAHSPG PCTVLYEGPV RGLCPFAPRN SNTMAAAALA APSLGFDGVI GVLVADTSLT DMHVVDVELS GPRGPTGRSF AVHTRRENPA EPGAVTGSAT VTAFWQSLLA CCQLPSRPGI HLC
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