About Leucine-rich repeat, immunoglobulin-like domain and transmembrane domain-containing protein 2
Leucine-rich repeat, immunoglobulin-like domain and transmembrane domain-containing protein 2 (LRIT2) is a protein
from Homo sapiens identified by UniProt accession
A6NDA9, 550 residues long.
MolForge cross-references it against 0 known binders and
14 disease associations.
Target properties
| Protein name | Leucine-rich repeat, immunoglobulin-like domain and transmembrane domain-containing protein 2 |
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| UniProt accession | A6NDA9 |
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| Gene | LRIT2 |
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| Organism | Homo sapiens |
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| Length | 550 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (14)
Diseases linked to this target (Open Targets).
- macula measurement · score 0.29
- refractive error measurement · score 0.29
- Myopia · score 0.20
- refractive error · score 0.15
- age at onset · score 0.12
- influenza A (H1N1) · score 0.09
- neurofibrillary tangles measurement · score 0.08
- Abnormality of refraction · score 0.04
- osteomyelitis · score 0.02
- triglyceride measurement · score 0.02
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-A6NDA9-F1 | alphafold | PREDICTED | 77.20 | — |
Amino-acid sequence (550 residues)
MASVFHYFLL VLVFLDTHAA QPFCLPGCTC SEESFGRTLQ CTSVSLGKIP GNLSEEFKQV RIENSPLFEM PQGSFINMST LEYLWLNFNN ISVIHLGALE HLPELRELRL EGNKLCSVPW TAFRATPLLR VLDLKRNKID ALPELALQFL VSLTYLDLSS NRLTVVSKSV FLNWPAYQKC RQPDCGAEIL SSLVVALHDN PWVCDCRLRG LVQFVKSITL PVILVNSYLI CQGPLSKAGQ LFHETELSAC MKPQISTPSA NITIRAGQNV TLRCLAQASP SPSIAWTYPL SMWREFDVLT SSTGEDTALS ELAIPAAHLV DSGNYTCMAS NSIGKSNLVI SLHVQPAQAL HAPDSLSIPS EGNAYIDLRV VKQTVHGILL EWLAVADTSK EEWFTLYIAS DEAFRKEVVH IGPGINTYAV DDLLPGTKYE ACLSLEGQPP HQGQCVAFVT GRDAGGLEAR EHLLHVTVVL CVVLLAVPVG AYAWAAQGPC SCSKWVLRGC LHRRKAPSCT PAAPQSKDGS FREHPAVCDD GEGHIDTEGD KEKGGTEDNS
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