TBC1 domain family member 3B (TBC1D3B)

About TBC1 domain family member 3B

TBC1 domain family member 3B (TBC1D3B) is a protein from Homo sapiens identified by UniProt accession A6NDS4, 549 residues long. MolForge cross-references it against 0 known binders and 8 disease associations.

Target properties

Protein name	TBC1 domain family member 3B
UniProt accession	A6NDS4
Gene	TBC1D3B
Organism	Homo sapiens
Length	549 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (8)

Diseases linked to this target (Open Targets).

Myopia · score 0.19
age at onset · score 0.19
macrophage inflammatory protein 1b measurement · score 0.16
refractive error · score 0.15
blood protein measurement · score 0.15
CCL4 measurement · score 0.15
visual perception measurement · score 0.12
C-C motif chemokine 3 measurement · score 0.10

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-A6NDS4-F1	alphafold	PREDICTED	59.08	—

Amino-acid sequence (549 residues)

MDVVEVAGSW WAQEREDIIM KYEKGHRAGL PEDKGPKPFR SYNNNVDHLG IVHETELPPL TAREAKQIRR EISRKSKWVD MLGDWEKYKS SRKLIDRAYK GMPMNIRGPM WSVLLNIEEM KLKNPGRYQI MKEKGKRSSE HIQRIDRDIS GTLRKHMFFR DRYGTKQREL LHILLAYEEY NPEVGYCRDL SHIAALFLLY LPEEDAFWAL VQLLASERHS LQGFHSPNGG TVQGLQDQQE HVVATSQSKT MGHQDKKDLC GQCSPLGCLI RILIDGISLG LTLRLWDVYL VEGEQALMPI TRIAFKVQQK RLTKTSRCGP WARFCNRFVD TWARDEDTVL KHLRASMKKL TRKQGDLPPP AKPEQGSSAS RPVPASRGRK TLCKGDRQAP PGPPARFPRP IWSASPPRAP RSSTPCPGGA VREDTYPVGT QGVPSPALAQ GGPQGSWRFL QWNSMPRLPT DLDVEGPWFR HYDFRQSCWV RAISQEDQLA PCWQAEHPAE RVRSAFAAPS TDSDQGTPFR ARDEQQCAPT SGPCLCGLHL ESSQFPPGF

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards