Protein FAM186A (FAM186A)

About Protein FAM186A

Protein FAM186A (FAM186A) is a protein from Homo sapiens identified by UniProt accession A6NE01, 2351 residues long. MolForge cross-references it against 0 known binders and 26 disease associations.

Target properties

Protein name	Protein FAM186A
UniProt accession	A6NE01
Gene	FAM186A
Organism	Homo sapiens
Length	2351 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (26)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.29
neutrophil count · score 0.22
hypertension · score 0.18
leukocyte count · score 0.13
heel bone mineral density · score 0.09
brain measurement · score 0.08
Immature Reticulocyte Fraction Measurement · score 0.08
sum of neutrophil and eosinophil counts · score 0.08
granulocyte count · score 0.07
myeloid white cell count · score 0.07

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-A6NE01-F1	alphafold	PREDICTED	50.34	—

Amino-acid sequence (2351 residues)

MFFKMKNEID NDPESEKCIK DSTIMRREPQ NILSPLMLPN LEIPFSVKDI ISRIERAQLH RAREDIDMQL SEIMNNVHRI MTRYTLVFNS SSERNVSLTE HKKKQRTNFL EKMATYAKTI EIREKTLANI LAWLEEWNDV LSEMTLMDVD EHHHWIAQME LLPDTLKAIE NNVKILSRFS TSFLDEKKKQ KKKILSRGTL WKSWKERVIK RPSTARALRP DQMISDQLAT NTKVSEIQGM LQELIGTTMF STLENNAIKY ISSTIVNLST ALSMLNDELK CVNFQSSTVY AHETSEAEKE LSLKIIRDLS NENEMLQQKL QDAEEKCEQL IRSKIVIEQL YAKLSTSSTL KVLPGPSPQS SRAIIKVGDT EDNMDNILDK ELENIVDEVQ RKETKDSGIK WDSTISYTAQ AERTPDLTEL RQQPVASEDI SEDSTKDNVS LKKGDFYQED ETDEYQSWKR SHKKATYVYE TSGPNLSDNK SGQKVSEAKP SQYYELQVLK KKRKEMKSFS EDKSKSPTEA KRKHLSLTET KSQGGKSGTS MMMLEQFRKV KRESPFDKRP TAAEIKVEPT TESLDKEGKG EIRSLVEPLS MIQFDDTAEP QKGKIKGKKH HISSGTITSK EEKTEEKEEL TKQVKSHQLV KSLSRVAKET SESTRVLESP DGKSEQSNLE EFQEAIMAFL KQKIDNIGKA FDKKTVPKEE ELLKRAEAEK LGIIKAKMEE YFQKVAETVT KILRKYKDTK KEEQVGEKPI KQKKVVSFMP GLHFQKSPIS AKSESSTLLS YESTDPVINN LIQMILAEIE SERDIPTVST VQKDHKEKEK QRQEQYLQEG QEQMSGMSLK QQLLGERNLL KEHYEKISEN WEEKKAWLQM KEGKQEQQSQ KQWQEEEMWK EEQKQATPKQ AEQEEKQKQR GQEEEELPKS SLQRLEEGTQ KMKTQGLLLE KENGQMRQIQ KEAKHLGPHR RREKGKEKQK PERGLEDLER QIKTKDQMQM KETQPKELEK MVIQTPMTLS PRWKSVLKDV QRSYEGKEFQ RNLKTLENLP DEKEPISITP PPSLQYSLPG ALPISGQPLT KCIHLTPQQA QEVGITLTPQ QAQAQGITLT LQQAQELGIP LTPQQAQALE ILFTPQQAQA LGIPLTPQQT QVQGITLTPQ QDQAPGISLT TQQAQKLGIP LTPQQAQALG IPLTPQQAQE LGIPLTPQQA QALRVSLTPQ QAQELGIPLT PQQAQALGIT LTLQQAQQLG IPLTPQQAQA LGITLTPKQV QELGIPLTPQ QAQALGITLT PKQAQELGIP LNPQQAQTLG IPLTPKQAQA LGIPFTPQQA QALGIPLTPQ QAQTQEITLT PQQAQALGMP LTTQQAQELG IPLTPQHAQA LGMPLTTQQA QELGIPLTPQ QAQALGMPLT TQQAQELGIP LTPQQAQELG IPFTPQQAQA QEITLTPQQA QALGMPLTAQ QAQELGITLT PQQAQELGIP LTPQQAQALG IPLIPPQAQE LGIPLTPQQA QALGILLIPP QAQELGIPLT PQQAQALGIP LIPPQAQELG IPLTPQQVQA LGIPLIPPQA QELEIPLTPQ QAQALGIPLT PQQAQELGIP LTPQQAQELG IPLTPQQAQA QGIPLTPQQA QALGISLTPQ QAQAQGITLT PQQAQALGVP ITPVNAWVSA VTLTSEQTHA LESPMNLEQA QEQLLKLGVP LTLDKAHTLG SPLTLKQVQW SHRPFQKSKA SLPTGQSIIS RLSPSLRLSL ASSAPTAEKS SIFGVSSTPL QISRVPLNQG PFAPGKPLEM GILSEPGKLG APQTLRSSGQ TLVYGGQSTS AQFPAPQAPP SPGQLPISRA PPTPGQPFIA GVPPTSGQIP SLWAPLSPGQ PLVPEASSIP GDLLESGPLT FSEQLQEFQP PATAEQSPYL QAPSTPGQHL ATWTLPGRAS SLWIPPTSRH PPTLWPSPAP GKPQKSWSPS VAKKRLAIIS SLKSKSVLIH PSAPDFKVAQ VPFTTKKFQM SEVSDTSEET QILRDTFAIE SFRTFQSHFT KYRTPVYQTP YTDERALLTL MKPTTSPSSL TTLLRTSQIS PLEWYQKSRF PPIDKPWILS SVSDTKKPKV MVPPSSPQEL EEKRYFVDVE AQKKNLILLN QAIKTCGLPS QLHTMARTLI IEILHMDTVQ LGYLFRKYIA YRLIQHARNN IMKRLKAIQN TGKGYEARNL HMMLSRLDDY GKKVMQVWTE KQKSLGQKRN QCLKKMIHVF NQLKKIHELN LSQPIPLIIE EKQIPASTTF VQKPFLKLLM EEDRTSDICK KFRQQEDQTE AIWNVDLSTS SYPIAEKTSM HSLWAQLGGY PDIPRLLQLE VQSTFRKSLA SLQSRVKKIP K

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards