BTB/POZ domain-containing protein 17 (BTBD17)

About BTB/POZ domain-containing protein 17

BTB/POZ domain-containing protein 17 (BTBD17) is a protein from Homo sapiens identified by UniProt accession A6NE02, 478 residues long. MolForge cross-references it against 0 known binders and 28 disease associations.

Target properties

Protein name	BTB/POZ domain-containing protein 17
UniProt accession	A6NE02
Gene	BTBD17
Organism	Homo sapiens
Length	478 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (28)

Diseases linked to this target (Open Targets).

benign prostatic hyperplasia · score 0.06
Testicular regression syndrome · score 0.06
46,XX ovotesticular disorder of sex development · score 0.05
Mayer-Rokitansky-Kuster-Hauser syndrome · score 0.04
renal hypodysplasia/aplasia 3 · score 0.04
PHF-tau measurement · score 0.04
Senior-Boichis syndrome · score 0.03
DNA methylation · score 0.03
kidney disease · score 0.03
hepatorenocardiac degenerative fibrosis · score 0.03

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-A6NE02-F1	alphafold	PREDICTED	84.68	—

Amino-acid sequence (478 residues)

MPRRGYSKPG SWGSFWAMLT LVGLVTHAAQ RADVGGEAAG TSINHSQAVL QRLQELLRQG NASDVVLRVQ AAGTDEVRVF HAHRLLLGLH SELFLELLSN QSEAVLQEPQ DCAAVFDKFI RYLYCGELTV LLTQAIPLHR LATKYGVSSL QRGVADYMRA HLAGGAGPAV GWYHYAVGTG DEALRESCLQ FLAWNLSAVA ASTEWGAVSP ELLWQLLQRS DLVLQDELEL FHALEAWLGR ARPPPAVAER ALRAIRYPMI PPAQLFQLQA RSAALARHGP AVADLLLQAY QFHAASPLHY AKFFDVNGSA FLPRNYLAPA WGAPWVINNP ARDDRSTSFQ TQLGPSGHDA GRRVTWNVLF SPRWLPVSLR PVYADAAGTA LPAARPEDGR PRLVVTPASS GGDAAGVSFQ KTVLVGARQQ GRLLVRHAYS FHQSSEEAGD FLAHADLQRR NSEYLVENAL HLHLIVKPVY HTLIRTPK

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards