Protein FAM181B (FAM181B)

About Protein FAM181B

Protein FAM181B (FAM181B) is a protein from Homo sapiens identified by UniProt accession A6NEQ2, 426 residues long. MolForge cross-references it against 0 known binders and 17 disease associations.

Target properties

Protein name	Protein FAM181B
UniProt accession	A6NEQ2
Gene	FAM181B
Organism	Homo sapiens
Length	426 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (17)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.28
bone density · score 0.24
urate measurement · score 0.24
central nervous system cancer · score 0.11
glioblastoma multiforme · score 0.11
adolescent idiopathic scoliosis · score 0.07
protein measurement · score 0.06
disease progression measurement · score 0.05
blood protein measurement · score 0.04
oligodendroglioma · score 0.01

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-A6NEQ2-F1	alphafold	PREDICTED	54.24	—

Amino-acid sequence (426 residues)

MAVQAALLST HPFVPFGFGG SPDGLGGAFG ALDKGCCFED DETGAPAGAL LSGAEGGDVR EATRDLLSFI DSASSNIKLA LDKPGKSKRK VNHRKYLQKQ IKRCSGLMGA APPGPPSPSA ADTPAKRPLA APSAPTVAAP AHGKAAPRRE ASQAAAAASL QSRSLAALFD SLRHVPGGAE PAGGEVAAPA AGLGGAGTGG AGGDVAGPAG ATAIPGARKV PLRARNLPPS FFTEPSRAGG GGCGPSGPDV SLGDLEKGAE AVEFFELLGP DYGAGTEAAV LLAAEPLDVF PAGASVLRGP PELEPGLFEP PPAVVGNLLY PEPWSVPGCS PTKKSPLTAP RGGLTLNEPL SPLYPAAADS PGGEDGRGHL ASFAPFFPDC ALPPPPPPHQ VSYDYSAGYS RTAYSSLWRS DGVWEGAPGE EGAHRD

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards