About Maestro heat-like repeat-containing protein family member 2A
Maestro heat-like repeat-containing protein family member 2A (MROH2A) is a protein
from Homo sapiens identified by UniProt accession
A6NES4, 1674 residues long.
MolForge cross-references it against 0 known binders and
27 disease associations.
Target properties
| Protein name | Maestro heat-like repeat-containing protein family member 2A |
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| UniProt accession | A6NES4 |
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| Gene | MROH2A |
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| Organism | Homo sapiens |
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| Length | 1674 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (27)
Diseases linked to this target (Open Targets).
- bilirubin measurement · score 0.63
- insomnia · score 0.27
- total blood protein measurement · score 0.27
- ulcerative colitis · score 0.26
- low density lipoprotein cholesterol measurement · score 0.15
- metabolite measurement · score 0.08
- blood protein measurement · score 0.07
- body fat percentage · score 0.07
- apolipoprotein B measurement · score 0.06
- total cholesterol measurement · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-A6NES4-F1 | alphafold | PREDICTED | 78.98 | — |
Amino-acid sequence (1674 residues)
MTEAITEAAV ASSEEVSEER DDLGPLELHD SGTFQQVVNL LDIIDSESAK TDTTGAGLDM RKTLASVIIM EKATTEPSVV INTLIRCLQV PEISTQRKVN IYNILQDIIQ QEGELEEQCV QRLVAIASKE MREIPEMEGY MKAEVASDTL VALSRNHFSL VMYELQHHLK PLNLTDEFVI ITLAKLANGN VFEFMPYMGI TLATIFTMLR LANEAKIRQA ICSAMETFCE TVQFYLKHLE ESVYPVMTEE EFALKVFPMY RYFVTVWLRH YNPEVKLGVI KSLKPMLGLL LPNDDLREQV YDYIPLLLAE YQGSLEVLFV TQVLRQILEL SVTTNTPVPQ MQLHTIFTEL HVQVCNKAPA QHQYSSQNLM EMVHCFVALA RSYPKELMKF FFSQMETNKE AVRVGTLNLI RAIVSADEPR MSIRAIYLAI RVVKNTISDT RSKVRMAILH IIGQLALCGY QERIKGWGLK YLSVQLTLST YKLTNRREKF YQRDLEERMV HKVTMDTVKI ITSSVSGMTT EFWVRLLCYI METDYVEALT PICISLTNLA EHQLHGQDVD VSVAGKSRQV DLPAPQKLLA RLLVLMSSPY KGEGRGIAML NLLRTLSQSI APSMADMWEL EIALLVRYLE EHTEFTWDQK AWEDKLIQFL RNSLKKTRGS SWSLRLSKEL NNQIASFDSP SLEKGFLYRA LGFTLATGLE ASKVEVLLLE LLYKTDYSND FDSEGVIMCF GLCARGQVKT VLNVLHDFEE RIQESEQSWQ ISAWRKDHPW RRETVKSALM VMYSCVASYC HPQLLLNLVD SPITAKIIHH YVSSCQDICL KMAFMKSVVQ VTKAINNIKD LEDFHFAQKT TLTSIIVAVI KAEPTDNLVS PVRALAMEAL SHLSKLKPFY STEENSELMD ISIHSVISLQ LPGEDNESIK TLYANALSSL EQLMESLLQR QLDPKGLQEM VQLLEKWILS EKEWEREKAV SLHLYLMWIY VHSTAVCIHL KLGQFGTMVG LIAPCTCDAH QRTRMASMNV LSSLLDLHAS QTCSLWGPSK QKELEKCKGD LQSTDVEKIF CASSRIAKVV CMEFSCDEVV SLIQKLCENT GAMNLQHDKA SVTWIAFFLQ MRAKELEDKV AEILSAILVH LPVVDHPEVR RLLIDGILLL AHHHQETILT SLLRQPLPME SHLAEVWLAV SENVPFARTM LHSLMGRLQS RLSPRISATS KADIWRLAAV DPLMTLCTIH LLIQKLDEND KLPDFLPDLI YTLLLQLGSS HRPEAAPPVL KMWKLVHTTP LPEEMNLQRV TIKSMQLLFK RVKSQHLAHT LDEQAVWDLL QDGGTFLEGV SLLARLCMQH VEGHRQRLAE LVLRGMDSEV LSCRISSTAV CFMSGPVLYQ EKLLKPAALL LEKGADQEED EALRVLSLRA LGNMALGAPK KVKQYRKVLL EKCLGPLREP VSNSVTAEGM EALTKILAEL REGDVGSSFD AMSEQCRIFF DNESELLRLK AFILFGKLAR VVGMSKKHFF KGEVKKAWIP LMLHSQDPCS NAAQACMATM FQCVHFWGWK SLEHPSGPSD TATDDKMTVF QTTMCSILTR KKPAVLYRFL LETMAYVKNN LSRIRIAACN LAGIIMKQMS THYLKKLDFP ALRNSLQELQ LDPDPGVRRA ALETLTVLDS CSQHGFLASP QGMS
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