About Glutaredoxin domain-containing cysteine-rich protein 2
Glutaredoxin domain-containing cysteine-rich protein 2 (GRXCR2) is a protein
from Homo sapiens identified by UniProt accession
A6NFK2, 248 residues long.
MolForge cross-references it against 0 known binders and
51 disease associations.
Target properties
| Protein name | Glutaredoxin domain-containing cysteine-rich protein 2 |
|---|
| UniProt accession | A6NFK2 |
|---|
| Gene | GRXCR2 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 248 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (51)
Diseases linked to this target (Open Targets).
- hearing loss, autosomal recessive · score 0.53
- deafness · score 0.46
- nonsyndromic genetic hearing loss · score 0.18
- autosomal recessive nonsyndromic hearing loss 1B · score 0.09
- autosomal dominant nonsyndromic hearing loss 7 · score 0.09
- deafness, aminoglycoside-induced · score 0.09
- autosomal dominant nonsyndromic hearing loss 17 · score 0.09
- electrocardiography · score 0.08
- autosomal dominant nonsyndromic hearing loss · score 0.08
- Non-syndromic genetic deafness · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-A6NFK2-F1 | alphafold | PREDICTED | 59.48 | — |
Amino-acid sequence (248 residues)
MEDPEKKLNQ KSDGKPRKVR FKISSSYSGR VLKQVFEDGQ ELESPKEEYP HSFLQESLET MDGVYGSGEV PRPQMCSPKL TAQRISVFRE GNAYTLAGGQ PRFNDYKAND HKPLPIIDFG KIIIYTNNLK IIRTPMDKRD FVRKILQKEE EAEEESLMNK EESYGGRDQH DRPLVEAEST LPQNRYTQEG DIPEDSCFHC RGSGSATCSL CHGSKFSMLA NRFKESYRAL RCPACNENGL QPCQICNQ
Explore Glutaredoxin domain-containing cysteine-rich protein 2 with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets