RNA binding protein fox-1 homolog 3 (RBFOX3)

About RNA binding protein fox-1 homolog 3

RNA binding protein fox-1 homolog 3 (RBFOX3) is a protein from Homo sapiens identified by UniProt accession A6NFN3, 312 residues long. MolForge cross-references it against 0 known binders and 296 disease associations.

Target properties

Protein name	RNA binding protein fox-1 homolog 3
UniProt accession	A6NFN3
Gene	RBFOX3
Organism	Homo sapiens
Length	312 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (296)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.37
Rolandic epilepsy · score 0.34
childhood epilepsy with centrotemporal spikes · score 0.33
autosomal dominant compelling helio-ophthalmic outburst syndrome · score 0.31
metastasis measurement · score 0.26
disease progression measurement · score 0.26
3-hydroxypropylmercapturic acid measurement · score 0.25
3-hydroxy-1-methylpropylmercapturic acid measurement · score 0.25
Orofacial cleft · score 0.20
generalised epilepsy · score 0.19

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-A6NFN3-F1	alphafold	PREDICTED	61.56	—

Amino-acid sequence (312 residues)

MAQPYPPAQY PPPPQNGIPA EYAPPPPHPT QDYSGQTPVP TEHGMTLYTP AQTHPEQPGS EASTQPIAGT QTVPQTDEAA QTDSQPLHPS DPTEKQQPKR LHVSNIPFRF RDPDLRQMFG QFGKILDVEI IFNERGSKGF GFVTFETSSD ADRAREKLNG TIVEGRKIEV NNATARVMTN KKTGNPYTNG WKLNPVVGAV YGPEFYAVTG FPYPTTGTAV AYRGAHLRGR GRAVYNTFRA APPPPPIPTY GAVVYQDGFY GAEIYGGYAA YRYAQPAAAA AAYSDSYGRV YAAADPYHHT IGPAATYSIG TM

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards