About Pyroglutamyl-peptidase 1-like protein
Pyroglutamyl-peptidase 1-like protein (PGPEP1L) is a protein
from Homo sapiens identified by UniProt accession
A6NFU8, 196 residues long.
MolForge cross-references it against 0 known binders and
25 disease associations.
Target properties
| Protein name | Pyroglutamyl-peptidase 1-like protein |
|---|
| UniProt accession | A6NFU8 |
|---|
| Gene | PGPEP1L |
|---|
| Organism | Homo sapiens |
|---|
| Length | 196 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (25)
Diseases linked to this target (Open Targets).
- body mass index · score 0.48
- body height · score 0.41
- lean body mass · score 0.35
- mean corpuscular hemoglobin · score 0.30
- neurodegenerative disease · score 0.29
- fat body mass · score 0.29
- BMI-adjusted waist circumference · score 0.26
- IGF-1 measurement · score 0.26
- PHF-tau measurement · score 0.24
- BMI-adjusted waist-hip ratio · score 0.24
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-A6NFU8-F1 | alphafold | PREDICTED | 89.29 | — |
Amino-acid sequence (196 residues)
MKPRTLVELS KLGLGNETVV QLRTLELPVD YREAKRRVTG IWEDHQPQLV VHVGMDTAAK AIILEQSGKN QGYRDADIRS FWPEGGVCLP GSPDVLESGV CMKAVCKRVA VEGVDVIFSR DAGRYVCDYT YYLSLHHGKG CAALIHVPPL SRGLPASLLG RALRVIIQEM LEEVGKPKHR AQFEENSTMV LPAKGN
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