Sphingosine-1-phosphate transporter MFSD2B (MFSD2B)

About Sphingosine-1-phosphate transporter MFSD2B

Sphingosine-1-phosphate transporter MFSD2B (MFSD2B) is a protein from Homo sapiens identified by UniProt accession A6NFX1, 504 residues long. MolForge cross-references it against 0 known binders and 242 disease associations.

Target properties

Protein name	Sphingosine-1-phosphate transporter MFSD2B
UniProt accession	A6NFX1
Gene	MFSD2B
Organism	Homo sapiens
Length	504 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (242)

Diseases linked to this target (Open Targets).

reticulocyte measurement · score 0.66
reticulocyte count · score 0.63
platelet crit · score 0.55
mean corpuscular volume · score 0.51
mean platelet volume · score 0.48
Immature Reticulocyte Fraction Measurement · score 0.44
HbA1c measurement · score 0.37
neurodegenerative disease · score 0.33
lymphocyte count · score 0.32
pulse pressure measurement · score 0.30

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-A6NFX1-F1	alphafold	PREDICTED	80.39	—

Amino-acid sequence (504 residues)

MAAPPAPAAK GSPQPEPHAP EPGPGSAKRG REDSRAGRLS FCTKVCYGIG GVPNQIASSA TAFYLQLFLL DIAQIPAAQV SLVLFGGKVS GAAADPVAGF FINRSQRTGS GRLMPWVLGC TPFIALAYFF LWFLPPFTSL RGLWYTTFYC LFQALATFFQ VPYTALTMLL TPCPRERDSA TAYRMTVEMA GTLMGATVHG LIVSGAHRPH RCEATATPGP VTVSPNAAHL YCIAAAVVVV TYPVCISLLC LGVKERPDPS APASGPGLSF LAGLSLTTRH PPYLKLVISF LFISAAVQVE QSYLVLFCTH ASQLHDHVQG LVLTVLVSAV LSTPLWEWVL QRFGKKTSAF GIFAMVPFAI LLAAVPTAPV AYVVAFVSGV SIAVSLLLPW SMLPDVVDDF QLQHRHGPGL ETIFYSSYVF FTKLSGACAL GISTLSLEFS GYKAGVCKQA EEVVVTLKVL IGAVPTCMIL AGLCILMVGS TPKTPSRDAS SRLSLRRRTS YSLA

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards