About Nuclear envelope integral membrane protein 2
Nuclear envelope integral membrane protein 2 (NEMP2) is a protein
from Homo sapiens identified by UniProt accession
A6NFY4, 417 residues long.
MolForge cross-references it against 0 known binders and
25 disease associations.
Target properties
| Protein name | Nuclear envelope integral membrane protein 2 |
|---|
| UniProt accession | A6NFY4 |
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| Gene | NEMP2 |
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| Organism | Homo sapiens |
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| Length | 417 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (25)
Diseases linked to this target (Open Targets).
- diastolic blood pressure · score 0.40
- peak expiratory flow · score 0.30
- systemic lupus erythematosus · score 0.29
- hemorrhoid · score 0.26
- mean arterial pressure · score 0.26
- blood phosphate measurement · score 0.24
- platelet count · score 0.22
- vital capacity · score 0.21
- systolic blood pressure · score 0.19
- pulse pressure measurement · score 0.19
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-A6NFY4-F1 | alphafold | PREDICTED | 80.20 | — |
Amino-acid sequence (417 residues)
MGPRQGRWWL LLWLPPLATL PVRGEAAAAA LSVRRCKALK EKDLIRTSES DCYCYNQNSQ VEWKYIWSTM QVKITSPGLF RIVYIAERHN CQYPENILSF IKCVIHNFWI PKESNEITII INPYRETVCF SVEPVKKIFN YMIHVNRNIM DFKLFLVFVA GVFLFFYART LSQSPTFYYS SGTVLGVLMT LVFVLLLVKR FIPKYSTFWA LMVGCWFASV YIVCQLMEDL KWLWYENRIY VLGYVLIVGF FSFVVCYKHG PLADDRSRSL LMWMLRLLSL VLVYAGVAVP QFAYAAIILL MSSWSLHYPL RACSYMRWKM EQWFTSKELV VKYLTEDEYR EQADAETNSA LEELRRACRK PDFPSWLVVS RLHTPSKFAD FVLGGSHLSP EEISLHEEQY GLGGAFLEEQ LFNPSTA
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