Succinate dehydrogenase assembly factor 1…

About Succinate dehydrogenase assembly factor 1, mitochondrial

Succinate dehydrogenase assembly factor 1, mitochondrial (SDHAF1) is a protein from Homo sapiens identified by UniProt accession A6NFY7, 115 residues long. MolForge cross-references it against 0 known binders and 28 disease associations.

Target properties

Protein name	Succinate dehydrogenase assembly factor 1, mitochondrial
UniProt accession	A6NFY7
Gene	SDHAF1
Organism	Homo sapiens
Length	115 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (28)

Diseases linked to this target (Open Targets).

mitochondrial complex II deficiency, nuclear type 1 · score 0.74
mitochondrial complex 2 deficiency, nuclear type 2 · score 0.65
mitochondrial disease · score 0.51
neurodegenerative disease · score 0.40
genetic disorder · score 0.19
lysosomal storage disease · score 0.14
Spastic paraparesis · score 0.01
Leukoencephalopathy · score 0.01
infection · score 0.01
infect · score 0.01

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-A6NFY7-F1	alphafold	PREDICTED	75.65	—

Amino-acid sequence (115 residues)

MSRHSRLQRQ VLSLYRDLLR AGRGKPGAEA RVRAEFRQHA GLPRSDVLRI EYLYRRGRRQ LQLLRSGHAT AMGAFVRPRA PTGEPGGVGC QPDDGDSPRN PHDSTGAPET RPDGR

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards

Succinate dehydrogenase assembly factor 1, mitochondrial (SDHAF1)