About Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase-like protein MGAT4D
Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase-like protein MGAT4D (MGAT4D) is a protein
from Homo sapiens identified by UniProt accession
A6NG13, 374 residues long.
MolForge cross-references it against 0 known binders and
20 disease associations.
Target properties
| Protein name | Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase-like protein MGAT4D |
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| UniProt accession | A6NG13 |
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| Gene | MGAT4D |
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| Organism | Homo sapiens |
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| Length | 374 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (20)
Diseases linked to this target (Open Targets).
- gastroesophageal reflux disease · score 0.05
- esophageal cancer · score 0.05
- Barrett's esophagus · score 0.05
- portal hypertension · score 0.04
- pancreatic adenocarcinoma · score 0.04
- esophageal adenocarcinoma · score 0.04
- familial visceral myopathy · score 0.03
- neuronal ceroid lipofuscinosis 1 · score 0.03
- X-linked diffuse leiomyomatosis - Alport syndrome · score 0.03
- peptic ulcer disease · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-A6NG13-F1 | alphafold | PREDICTED | 84.66 | — |
Amino-acid sequence (374 residues)
MRTKQVNLLI TLVAVALFSF SCFSIYRITQ TNNQLINCRN HILEFKENML HLRNKTEKNT QEMMKVLNRM KYEITKREIL SGNLVAQKAD ILNKNETVSN TFEDLKFFFP HLRKEGRIYP DVIIGKGKTG VSFALGISTV NRGNYSYLKQ TLTSVVSRMT LSQEKDSVVI VLVADSNEDY LHSVVKMITK KFKRQVRSGS LEVISIPAFL YSSMLNAKHL AEASQKLASW RIKQVLDFCI LLLYAQPKAK YYLQLEDDII AKEMYFTKIT DFVGNISSNN WFFIEFSMLG FIGKLFRSED LTHFVRFFLM FYKEKPIDWL LNDIFQVKVC DAGEDLRNCM KRKKQIRIQY KPSLFQHVGI HSSFPRKEQY EKKI
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