About DDB1- and CUL4-associated factor 8-like protein 1
DDB1- and CUL4-associated factor 8-like protein 1 (DCAF8L1) is a protein
from Homo sapiens identified by UniProt accession
A6NGE4, 600 residues long.
MolForge cross-references it against 0 known binders and
14 disease associations.
Target properties
| Protein name | DDB1- and CUL4-associated factor 8-like protein 1 |
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| UniProt accession | A6NGE4 |
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| Gene | DCAF8L1 |
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| Organism | Homo sapiens |
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| Length | 600 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (14)
Diseases linked to this target (Open Targets).
- neuroticism measurement · score 0.03
- neoplasm · score 0.03
- hepatocellular carcinoma · score 0.02
- breast carcinoma · score 0.01
- carcinoma · score 0.01
- Fibroadenoma · score 0.01
- cancer · score 0.01
- Lentivirus Infections · score 0.00
- invasive breast ductal carcinoma · score 0.00
- papillary thyroid carcinoma · score 0.00
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-A6NGE4-F1 | alphafold | PREDICTED | 73.29 | — |
Amino-acid sequence (600 residues)
MSHQEGSTGG LPDLVTESLF SSPEEQSGVA AVTAASSDIE MAATEPSTGD GGDTRDGGFL NDASTENQNT DSESSSEDVE LESMGEGLFG YPLVGEETER EEEEEEMEEE GEEEEQPRMC PRCGGTNHDQ CLLDEDQALE EWISSETSAL PRSRWQVLTA LRQRQLGSSA RFVYEACGAR TFVQRFRLQY LLGSHAGSVS TIHFNQRGTR LASSGDDLRV IVWDWVRQKP VLNFESGHDI NVIQAKFFPN CGDSTLAMCG HDGQVRVAEL INASYCENTK RVAKHRGPAH ELALEPDSPY KFLTSGEDAV VFTIDLRQDR PASKVVVTRE NDKKVGLYTI SMNPANIYQF AVGGHDQFVR IYDQRRIDKK ENNGVLKKFT PHHLVYCDFP TNITCVVYSH DGTELLASYN DEDIYLFNSS LSDGAQYVKR YKGHRNNDTI KCVNFYGPRS EFVVSGSDCG HVFFWEKSSS QIIQFMEGDR GDIVNCLEPH PYLPVLATSG LDQHVRIWTP TAKTATELTG LKDVIKKNKQ ERDEDNLNYT DSFDNRMLRF FVRHLLQRAH QPGWRDHGAE FPDEEELDES SSTSDTSEEE GQDRVQCIPS
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