Ankyrin repeat domain-containing protein 61 (ANKRD61)

About Ankyrin repeat domain-containing protein 61

Ankyrin repeat domain-containing protein 61 (ANKRD61) is a protein from Homo sapiens identified by UniProt accession A6NGH8, 418 residues long. MolForge cross-references it against 0 known binders and 9 disease associations.

Target properties

Protein name	Ankyrin repeat domain-containing protein 61
UniProt accession	A6NGH8
Gene	ANKRD61
Organism	Homo sapiens
Length	418 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (9)

Diseases linked to this target (Open Targets).

mean corpuscular volume · score 0.23
reticulocyte count · score 0.14
mean corpuscular hemoglobin concentration · score 0.10
reticulocyte measurement · score 0.10
Immature Reticulocyte Fraction Measurement · score 0.10
Red cell distribution width · score 0.07
mean corpuscular hemoglobin · score 0.02
blood phosphate measurement · score 0.02
Crohn's disease · score 0.01

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-A6NGH8-F1	alphafold	PREDICTED	84.89	—

Amino-acid sequence (418 residues)

MGNITRKGSR DLVVDSAKSL EDGPSAALHS KLYEAIMRED CTTIEVLLRN HPVNQPITIL PNSASNRLLL TQPTESIIPI HLAAKYHKAQ SLLCLLRHGA DPEVRDTTGL TTLNLMLLHW PVTSTTWAKP GNRTHRILTD IQNSSITCLR ILCAHGAQVN TQGEISNKRS PLHLAIAYGC YPVLSILTQN GADVNAINEA SMTPLHMAAN MLNKEMMETL IAYGANVNCA VSSTGNTPLK LAVCTASSKA GRLLGAGVSC IRLLLTHGAK VNAQDYKGQT AIHEACFGGR EAIINLLLEF EANVNILTRN GESPIYMYLQ RSCNVRDTAL LARLLYHTYP LRMTNNQGIL PAGIMLPEFR LLRDTLIKQS QKPLSLQGIC KRNIRNIYGE KYKQHLKQFL PVTIWNSVYC CYDLAYTS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards