About Maestro heat-like repeat-containing protein family member 6
Maestro heat-like repeat-containing protein family member 6 (MROH6) is a protein
from Homo sapiens identified by UniProt accession
A6NGR9, 719 residues long.
MolForge cross-references it against 0 known binders and
27 disease associations.
Target properties
| Protein name | Maestro heat-like repeat-containing protein family member 6 |
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| UniProt accession | A6NGR9 |
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| Gene | MROH6 |
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| Organism | Homo sapiens |
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| Length | 719 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (27)
Diseases linked to this target (Open Targets).
- schizophrenia · score 0.29
- HbA1c measurement · score 0.17
- C-reactive protein measurement · score 0.16
- aspartate aminotransferase measurement · score 0.14
- interleukin 18 measurement · score 0.14
- ulcer disease · score 0.13
- serum alanine aminotransferase measurement · score 0.12
- autosomal recessive non-syndromic intellectual disability · score 0.11
- metabolite measurement · score 0.09
- monocyte count · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-A6NGR9-F1 | alphafold | PREDICTED | 75.75 | — |
Amino-acid sequence (719 residues)
MAGGVWGRSR AREAPVGALT LTALTEGIRA RQGQPQGPPS AGPQPKSWEV KPEAEPQTQA LTAPSEAEPG RGATVPEAGS EPCSLNSALE PAPEGPHQVP QSSWEEGVLA DLALYTAACL EEAGFAGTQA TVLTLSSALE ARGERLEDQV HALVRGLLAQ VPSLAEGRPW RAALRVLSAL ALEHARDVVC ALLPRSLPAD RVAAELWRSL SRNQRVNGQV LVQLLWALKG ASGPEPQALA ATRALGEMLA VSGCVGATRG FYPHLLLALV TQLHKLARSP CSPDMPKIWV LSHRGPPHSH ASCAVEALKA LLTGDGGRMV VTCMEQAGGW RRLVGAHTHL EGVLLLASAM VAHADHHLRG LFADLLPRLR SADDPQRLTA MAFFTGLLQS RPTARLLREE VILERLLTWQ GDPEPTVRWL GLLGLGHLAL NRRKVRHVST LLPALLGALG EGDARLVGAA LGALRRLLLR PRAPVRLLSA ELGPRLPPLL DDTRDSIRAS AVGLLGTLVR RGRGGLRLGL RGPLRKLVLQ SLVPLLLRLH DPSRDAAESS EWTLARCDHA FCWGLLEELV TVAHYDSPEA LSHLCCRLVQ RYPGHVPNFL SQTQGYLRSP QDPLRRAAAV LIGFLVHHAS PGCVNQDLLD SLFQDLGRLQ SDPKPAVAAA AHVSAQQVAM LARARGCPRG PRLLRIAPRP ARPPPVFADS PFQRRSVAGR WGCSGPRRA
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