Serine incorporator 4 (SERINC4)

About Serine incorporator 4

Serine incorporator 4 (SERINC4) is a protein from Homo sapiens identified by UniProt accession A6NH21, 518 residues long. MolForge cross-references it against 0 known binders and 7 disease associations.

Target properties

Protein name	Serine incorporator 4
UniProt accession	A6NH21
Gene	SERINC4
Organism	Homo sapiens
Length	518 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (7)

Diseases linked to this target (Open Targets).

hemoglobin A1 measurement · score 0.03
blood protein measurement · score 0.03
triglyceride measurement · score 0.03
high density lipoprotein cholesterol measurement · score 0.02
susceptibility to urinary tract infection measurement · score 0.02
type 2 diabetes mellitus · score 0.02
neoplasm · score 0.00

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-A6NH21-F1	alphafold	PREDICTED	71.40	—

Amino-acid sequence (518 residues)

MVGAKAGPSP GTSLGLAQQH SGGSSVLVKS PFCQVCCCGP APCASCCHSR WPSLTASTCS RLFYILLHVG ASAICCLLLS RTVVERVWGK THRIQMPSGL CAHLFGLSDC PVLSGSGAVY RVCAGTATFH LLQAVLLVHL HSPTSPRAQL HNSFWLLKLL FLLGLCAIAF CIPDEHLFPA WHYIGICGGF AFILLQLVLI TAFAHSWNKN WQTGAAQDCS WFLAVLLATL GFYSMAGVGA VLLFHYYTHP AGCLLNKMLL SLHLCFCGLI SFLSIAPCIR LKQPRSGLLQ ASVISCYIMY LTFSALSSRP PERVILQGQN HTLCLPGLSK MEPQTPDISL AMLSASIMYA CVLFACNEAS YLAEVFGPLW IVKVYSYEFQ KPSLCFCCPE TVEADKGQRG GAARPADQET PPAPPVQVQH LSYNYSAFHF VFFLASLYVM VTLTNWFSYE GAELEKTFIK GSWATFWVKV ASCWACVLLY LGLLLAPLCW PPTQKPQPLI LRRRRHRIIS PDNKYPPV

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards