RNA 2'-O-methyltransferase FBLL1 (FBLL1)

About RNA 2'-O-methyltransferase FBLL1

RNA 2'-O-methyltransferase FBLL1 (FBLL1) is a protein from Homo sapiens identified by UniProt accession A6NHQ2, 334 residues long. MolForge cross-references it against 0 known binders and 23 disease associations.

Target properties

Protein name	RNA 2'-O-methyltransferase FBLL1
UniProt accession	A6NHQ2
Gene	FBLL1
Organism	Homo sapiens
Length	334 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (23)

Diseases linked to this target (Open Targets).

HbA1c measurement · score 0.23
hemoglobin A1 measurement · score 0.19
body mass index · score 0.07
body height · score 0.05
diastolic blood pressure · score 0.04
self reported educational attainment · score 0.04
gut microbiome measurement · score 0.04
lean body mass · score 0.03
appendicular lean mass · score 0.03
BMI-adjusted hip circumference · score 0.03

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-A6NHQ2-F1	alphafold	PREDICTED	75.54	—

Amino-acid sequence (334 residues)

MKSAASSRGG GGGGRGGGGW GSWGGGRGGG GGAGKGGGGD GGGQGGKGGF GARARGFGGG GRGRGRGGGD GKDRGGGGQR RGGVAKSKSR RRKGAMVVSV EPHRHEGVFI YRGAEDALVT LNMVPGQSVY GERRVTVTEG GVKQEYRTWN PFRSKLAAAI LGGVDQIHIK PKSKVLYLGA ASGTTVSHVS DIIGPDGLVY AVEFSHRAGR DLVNVAKKRT NIIPVLEDAR HPLKYRMLIG MVDVIFADVA QPDQSRIVAL NAHTFLRNGG HFLISIKANC IDSTASAEAV FASEVRKLQQ ENLKPQEQLT LEPYERDHAV VVGVYRPLPK SSSK

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards